An evaluation of preimplantation genetic diagnosis outcomes in Johannesburg, South Africa
| dc.contributor.author | Carzis Bianca | |
| dc.date.accessioned | 2023-03-30T07:12:50Z | |
| dc.date.available | 2023-03-30T07:12:50Z | |
| dc.date.issued | 2017 | |
| dc.description | A research report (in the format of a "submissible" paper) submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of Science in Medicine (Genetic Counselling) | |
| dc.description.abstract | Preimplantation genetic diagnosis (PGD) involves testing embryos that were created using artificial reproductive technology for a familial genetic condition before being transferred to a woman's uterus. The aim of this study was to determine the number and nature of PGD cases managed through the Division of Human Genetics at the University of the Witwatersrand and National Health Laboratory Service, and assess the outcomes at various stages of the PGD process, including a cost estimation of PGD. The files of 22 PGD couples were included in a retrospective case review. In total, there were 42 IVF/ICSI cycles included in the analysis. The clinical pregnancy rate per embryo transfer was 29.3%. Overall, 10/22 (45.5%) couples had a successful cycle resulting in a liveborn baby. On average, one cycle of PGD costs USO 9,525 (ZAR 125,578). This study shows that our PGD success rates are comparable to those achieved globally. | |
| dc.description.librarian | AC2023 | |
| dc.identifier.uri | https://hdl.handle.net/10539/34812 | |
| dc.language.iso | en | |
| dc.title | An evaluation of preimplantation genetic diagnosis outcomes in Johannesburg, South Africa | |
| dc.type | Dissertation |