The effects of miglitol on the pharmacokinetics of phenytoin in healthy volunteers
| dc.contributor.author | Richardt, Denise | |
| dc.date.accessioned | 2018-06-04T12:48:06Z | |
| dc.date.available | 2018-06-04T12:48:06Z | |
| dc.date.issued | 1996-12-22 | |
| dc.description | Dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science In Medicine | en_ZA |
| dc.description.abstract | The interaction between miglitol, an a-glucosidase inhibitor used as an adjunct therapy in diabetes, and phenytoin, an anticonvulsant primarily used in the treatment of epilepsy, was studied over 26 days. Twenty-four healthy male volunteers took part in a placebo controlled, double blind, cross-over study in two phases, to determine the effects of multiple 100mg doses of miglitol on a single 400mg dose of phenytoin sodium. Miglitol or placebo was administered three times daily from Day 1 to Day 5. Phenytoin was administered as a single dose on Day 3 of each phase, after which blood samples were taken at regular intervals. A washout period of 14 days separated the two phases. | en_ZA |
| dc.description.librarian | IT2018 | en_ZA |
| dc.identifier.uri | https://hdl.handle.net/10539/24572 | |
| dc.language.iso | en | en_ZA |
| dc.subject.mesh | Pharmacokinetics | |
| dc.subject.mesh | Phenytoin | |
| dc.subject.mesh | Diabetes | |
| dc.title | The effects of miglitol on the pharmacokinetics of phenytoin in healthy volunteers | en_ZA |
| dc.type | Thesis | en_ZA |