Neurodevelopmental assessment of HIV-exposed uninfected and early-treated HIV-infected children: study protocol

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dc.contributor.authorStrehlau, Renate
dc.contributor.authorvan Aswegen, Tamryn
dc.contributor.authorPotterton, Joanne
dc.date.accessioned2024-10-09T09:51:18Z
dc.date.available2024-10-09T09:51:18Z
dc.date.issued2018-04
dc.departmentPaediatrics
dc.description.abstractObjective: Sub-Saharan Africa has the highest prevalence of children at risk of not achieving their developmental potential, attributable largely to the human immunodeficiency virus (HIV) pandemic coupled with negative environmental factors. Childhood developmental stimulation programmes can mitigate adverse outcomes. Methods: Neonates testing HIV positive at birth will be initiated on antiretroviral treatment (ART) and receive an age appropriate stimulation program, updated at 3 monthly intervals through the first year of life. Neurodevelopment at 12 months of age will be assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Outcomes will be compared with HIV-infected and HIV-exposed uninfected children (HEU) not having received the stimulatory intervention. Associations between neurodevelopmental outcomes, environmental factors, and parental stress will be investigated. The study will take place at a single site in Johannesburg, South Africa. This non-randomised controlled intervention study, with a single non-blinded comparative intervention group, aims to investigate whether an early childhood stimulation programme used in conjunction with ART initiated at birth can positively impact neurodevelopmental outcomes at 1 year of age in children infected with HIV.
dc.description.submitterPM2024
dc.facultyFaculty of Health Sciences
dc.identifier0000-0001-9113-6584
dc.identifier.citationStrehlau, R., van Aswegen, T. & Potterton, J. Neurodevelopmental assessment of HIV-exposed uninfected and early-treated HIV-infected children: study protocol. BMC Res Notes 11, 235 (2018). https://doi.org/10.1186/s13104-018-3331-8
dc.identifier.issn1756-0500 (online)
dc.identifier.other10.1186/s13104-018-3331-8
dc.identifier.urihttps://hdl.handle.net/10539/41464
dc.journal.titleBMC Research Notes
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofseriesVol. 11; a235
dc.rights© The Author(s) 2018. Open Access, This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
dc.schoolSchool of Public Health
dc.subjectEarly childhood development
dc.subjectHIV
dc.subjectEarly antiretroviral treatment
dc.subject.otherSDG-3: Good health and well-being
dc.titleNeurodevelopmental assessment of HIV-exposed uninfected and early-treated HIV-infected children: study protocol
dc.typeArticle
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