The effect of a ketogenic diet versus a high-carbohydrate, low-fat diet on sleep, cognition, thyroid function, and cardiovascular health independent of weight loss: study protocol for a randomized controlled trial
| dc.article.end-page | 9 | |
| dc.article.start-page | 1 | |
| dc.contributor.author | Iacovides, Stella | |
| dc.contributor.author | Meiring, Rebecca M. | |
| dc.date.accessioned | 2024-09-13T09:07:12Z | |
| dc.date.available | 2024-09-13T09:07:12Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Background: Many physiological health benefits observed after following a ketogenic diet (KD) can be attributed to the associated weight loss. The KD has become more prominent as a popular health choice, not only in obese/overweight individuals, but also in healthy adults. The study aims to determine the effects of a KD, independent of weight loss, on various aspects of physiological health including: sleep, thyroid function, cognition, and cardio-metabolic health. The study will also aim to determine whether a change in basal metabolic rate may be associated with any changes observed. Methods: Twenty healthy men and women between 18 and 50 years of age will take part in this study. In a randomized controlled, cross-over design, participants will follow two isocaloric diets: a high-carbohydrate, low-fat diet (55% CHO, 20% fat, 25% protein) and a KD (15% CHO, 60% fat, 25% protein). Each dietary intervention will last for a minimum of 3 weeks, with a 1-week washout period in between. Before and after each diet, participants will be assessed for sleep quality, cognitive function, thyroid function, and basal metabolic rate. A blood sample will also be taken for the measurement of cardio-metabolic and immune markers. Discussion: The present study will help in understanding the potential effects of a KD on aspects of physiological health in healthy adults, without the confounding factor of weight loss. The study aims to fill a significant void in the academic literature with regards to the benefits and/or risks of a KD in a healthy population, but will also explore whether diet-related metabolic changes may be responsible for the changes observed in physiological health. | |
| dc.description.sponsorship | Health Sciences’ Seed Funding for Research. | |
| dc.description.sponsorship | Movement Physiology Research Laboratory. | |
| dc.description.sponsorship | Brain Function Research Group, University of the Witwatersrand | |
| dc.description.submitter | PM2024 | |
| dc.faculty | Faculty of Health Sciences | |
| dc.identifier | 0000-0003-2807-91 | |
| dc.identifier.citation | Iacovides, S., & Meiring, R. M. (2018). The effect of a ketogenic diet versus a high-carbohydrate, low-fat diet on sleep, cognition, thyroid function, and cardiovascular health independent of weight loss: study protocol for a randomized controlled trial. Trials, 19(1), 62. https://doi.org/10.1186/s13063-018-2462-5 | |
| dc.identifier.issn | 1745-6215 (online) | |
| dc.identifier.other | 10.1186/s13063-018-2462-5 | |
| dc.identifier.uri | https://hdl.handle.net/10539/40764 | |
| dc.journal.title | Trials | |
| dc.language.iso | en | |
| dc.publisher | BMC | |
| dc.relation.ispartofseries | Vol.19; No. 62 | |
| dc.rights | © The Author(s). 2018 Open Access,This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. | |
| dc.school | School of Physiology | |
| dc.subject | High-fat | |
| dc.subject | Low-carbohydrate | |
| dc.subject | Ketogenic diet | |
| dc.subject | Metabolism | |
| dc.subject | Cognition | |
| dc.subject | Thyroid function | |
| dc.subject | Sleep | |
| dc.subject | Healthy participants | |
| dc.subject.other | SDG-3: Good health and well-being | |
| dc.title | The effect of a ketogenic diet versus a high-carbohydrate, low-fat diet on sleep, cognition, thyroid function, and cardiovascular health independent of weight loss: study protocol for a randomized controlled trial | |
| dc.type | Article |