An audit of oral lesions associated with HPV infection in the Oral Pathology Department, Wits Oral Health Centre
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Date
2020
Authors
Golele, Sagwati
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Abstract
ABSTRACT:
Human papillomavirus (HPV) is a DNA tumour virus that has been increasingly seen in both
healthy and immunocompromised individuals. This virus belongs to the papillomaviridae family
that infects epithelial cells exclusively. The clinical presentation and microscopic features of HPVassociated oral lesions vary depending on the specific genotype and the anatomical site involved.
Aim: The study aimed to report on the oral lesions associated with HPV infection, histologically
diagnosed in the Department of Oral Pathology at Wits Oral Health Centre (WOHC).
Methods: The study population comprised of 128 patient records of HPV associated oral lesions
that were histologically diagnosed in the Oral Pathology Department. A descriptive analysis of the
data was carried out.
Results: The results showed a strong association of HPV-associated oral lesions with age and
HIV-status than with gender. The lesions were of a low risk HPV subtypes and focal epithelial
hyperplasia was the most commonly occurring lesion.
Conclusion: In light of the results from this study, it was evident that there was a strong
association between occurrence of HPV-associated oral lesions with age and HIV-status of
patient. In a country where HIV prevalence is alarmingly high, studies looking at association of
HPV occurrence, HIV infection and demographics of the population needed to be investigated
Description
A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Science in Dentistry, 2020
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Citation
Golele, Sagwati (2020) An audit of oral lesions associated with HPV infection in the Oral Pathology Department, Wits Oral Health Centre, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/30463>