Expression of the hepatitis b virus genome in chronic hepatitis b carriers

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dc.contributor.authorBowyer., Sheila. Mary.
dc.date.accessioned2019-03-27T10:22:57Z
dc.date.available2019-03-27T10:22:57Z
dc.date.issued1986-12-15
dc.descriptionA Dissertation Submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg for the degree of Master of Science Johannesburg 1986en_ZA
dc.description.abstractThe methylation status of CCGG sites in hepatitis B virus (HBV) DNA was examined to determine whether methylation could be responsible for the selective expression of the HBV surface gene in the progression of chronic hepatitis B infection and hepatocellular carcinoma. Total cellular DNA, determined to have sufficient HBV DNA, was digested with the restriction endonucleases Mspl and Hpall, to determine whether the HBV DNA was methylated, or HindiII, to determine whether the HBV DNA was integrated. The cleavage fragments were analysed by Southern blotting and hybridisation to •32p- labelled HBV DNA.en_ZA
dc.description.librarianIT2019en_ZA
dc.identifier.urihttps://hdl.handle.net/10539/26645
dc.language.isoenen_ZA
dc.subject.meshhepatitis B virus
dc.subject.meshCarcinoma, Hepatocellular
dc.titleExpression of the hepatitis b virus genome in chronic hepatitis b carriersen_ZA
dc.typeThesisen_ZA
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