Construction and screening of a DNA library to detect integrated hepatitis B virus DNA
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Date
2016-08-16
Authors
Bondonno, Catherine Patricia
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Abstract
Hepatitis B virus (HBV) infection resulting in integration of the viral DNA into host
liver cell DNA is associated with the development of hepatocellular carcinoma
(HCC). This is indicated by epidemiological trends, molecular studies and studies of
animal models infected with viruses closely related to HBv. However, little is
known about the mechanism by which the integrated HBV DNA includes HCC
despite continuing analysis of the integrated HBV DNA and its surrounding cellular
sequences. [Abbreviated Abstract. Open document to view full version]
Description
Degree awarded with distinction on 6 December l995.
A dissertation submitted to the Faculty of Science, University the Witwatersrand,
in fulfilment of the requirements for the degree of Master of Science.
March. 1995