New purine analogues as inhibitors of purine metabolism

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dc.contributor.authorRama, Dhirajlal Bhagwan Kasan
dc.date.accessioned2015-07-20T13:26:48Z
dc.date.available2015-07-20T13:26:48Z
dc.date.issued2015
dc.description.abstractAbstract Phleomycin, a copper containing protein, has a broad range of antibiotics (3,4,6) anti tumor (7,9), and anti-viral (5) activity. At low concentrations it induces DNA breakdown and death in growing culture is of E. coli B, but has little effect on stationary phase bacteria (10) . However, its action can be strongly potentiated on stationary phase cells by the addition of certain compounds. This phenomenon is termed amplification.The mechanism of amplification phleomycin is not well understood. In this study the effects of various purine and pyrimidine analogues reported as amplifiers of phleomycin (2) were investigated on several aspects of nucleotide metabolism.
dc.identifier.urihttp://hdl.handle.net/10539/18104
dc.language.isoenen_ZA
dc.subject.lcshPurines
dc.titleNew purine analogues as inhibitors of purine metabolismen_ZA
dc.typeThesisen_ZA
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