The effects of cyclic nucleotides and agents which affect their intracellular accumulation on neutrophil motility
The cell type exclusively dealt with in this thesis is the human blood neutrophil, which is also referred to in the text as polymorphonuclear leukocyte (PMN). The experimental work in this thesis has been accomplished using one immunological and a number of biochemical investigative techniques. The former is the Boyden technique (Boyden, 1962) for the quantitative assessment of leucocyte motility.
A Thesis Submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg for the Degree of Doctor of Philosophy,