The synthesis of 3,5-disubstituted indolizidines

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dc.contributor.authorCheesman, Penelope, Sue
dc.date.accessioned2017-04-20T08:45:47Z
dc.date.available2017-04-20T08:45:47Z
dc.date.issued1996
dc.descriptionA dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science. January 1996.en_ZA
dc.description.abstractAspects of the literature of the ant venom alkaloid monomorine I and its stereoisomers were reviewed. Racemic 5-butyl-2-pyrrolidinone was synthesised in two steps from methyl acrylate and 1-nitropentane, A thionation step yielded 5-butylpyrrolidine-2-thione. The Michael addition reaction between 5-butylpyrrolidine-2-thione and ethyl crotonate proceeded with difficulty to form a separable mixture of diastereomers of 5-butyl-l-(2-ethoxycarbonyl-l-methylethyl) pyrrolidine-2-thione. [Abbreviated Abstract. Open document to view full version]en_ZA
dc.description.librarianAC2017en_ZA
dc.format.extentOnline resource (151 leaves)
dc.identifier.citationCheesman, Penelope, Sue (1996) The synthesis of 3,5-disubstituted indolizidines, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/22411>
dc.identifier.urihttp://hdl.handle.net/10539/22411
dc.language.isoenen_ZA
dc.subject.lcshIndole alkaloids--Synthesis
dc.subject.lcshOrganic compounds--Synthesis
dc.titleThe synthesis of 3,5-disubstituted indolizidinesen_ZA
dc.typeThesisen_ZA
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