The synthesis of 3,5-disubstituted indolizidines
| dc.contributor.author | Cheesman, Penelope, Sue | |
| dc.date.accessioned | 2017-04-20T08:45:47Z | |
| dc.date.available | 2017-04-20T08:45:47Z | |
| dc.date.issued | 1996 | |
| dc.description | A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science. January 1996. | en_ZA |
| dc.description.abstract | Aspects of the literature of the ant venom alkaloid monomorine I and its stereoisomers were reviewed. Racemic 5-butyl-2-pyrrolidinone was synthesised in two steps from methyl acrylate and 1-nitropentane, A thionation step yielded 5-butylpyrrolidine-2-thione. The Michael addition reaction between 5-butylpyrrolidine-2-thione and ethyl crotonate proceeded with difficulty to form a separable mixture of diastereomers of 5-butyl-l-(2-ethoxycarbonyl-l-methylethyl) pyrrolidine-2-thione. [Abbreviated Abstract. Open document to view full version] | en_ZA |
| dc.description.librarian | AC2017 | en_ZA |
| dc.format.extent | Online resource (151 leaves) | |
| dc.identifier.citation | Cheesman, Penelope, Sue (1996) The synthesis of 3,5-disubstituted indolizidines, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/22411> | |
| dc.identifier.uri | http://hdl.handle.net/10539/22411 | |
| dc.language.iso | en | en_ZA |
| dc.subject.lcsh | Indole alkaloids--Synthesis | |
| dc.subject.lcsh | Organic compounds--Synthesis | |
| dc.title | The synthesis of 3,5-disubstituted indolizidines | en_ZA |
| dc.type | Thesis | en_ZA |
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