SHBG, free testosterone, and Type 2 Diabetes risk in middle-aged African men: a longitudinal study
dc.contributor.author | Norris, Shane | |
dc.contributor.author | Seipone, Ikanyeng D. | |
dc.contributor.author | Mendham, Amy E. | |
dc.contributor.author | Storbeck, Karl-Heinz | |
dc.contributor.author | Oestlund, Imken | |
dc.contributor.author | Kufe, Clement N. | |
dc.contributor.author | Chikowore, Tinashe | |
dc.contributor.author | Masemola, Maphoko | |
dc.contributor.author | Crowther, Nigel J. | |
dc.contributor.author | Kengne, Andre Pascal | |
dc.contributor.author | Olsson, Tommy | |
dc.contributor.author | Brown, Todd | |
dc.contributor.author | Micklesfield, Lisa K. | |
dc.contributor.author | Goedecke, Julia H. | |
dc.date.accessioned | 2024-08-12T08:33:56Z | |
dc.date.available | 2024-08-12T08:33:56Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Objectives: To investigate longitudinal changes in SHBG and free testosterone (free T) levels among Black middle-aged African men, with and without coexistent HIV, and explore associations with incident dysglycaemia and measures of glucose metabolism. Design: This longitudinal study enrolled 407 Black South African middle-aged men, comprising primarily 322 men living without HIV (MLWOH) and 85 men living with HIV (MLWH), with normal fasting glucose at enrollment. Follow-up assessments were conducted after 3.1 ± 1.5 years. Methods: At baseline and follow-up, SHBG, albumin, and total testosterone were measured and free T was calculated. An oral glucose tolerance test at follow-up determined dysglycaemia (impaired fasting glucose, impaired glucose tolerance, type 2 diabetes) and glucose metabolism parameters including insulin sensitivity (Matsuda index), insulin resistance (homeostasis model assessment of insulin resistance), and beta(β)- cell function (disposition index). The primary analysis focussed on MLWOH, with a subanalysis on MLWH to explore whether associations in MLWOH differed from MLWH. Results: The prevalence of dysglycaemia at follow-up was 17% (n = 55) in MLWOH. Higher baseline SHBG was associated with a lower risk of incident dysglycaemia (odds ratio 0.966; 95% confidence interval 0.945-0.987) and positively associated with insulin sensitivity (β = 0.124, P < .001) and β-cell function (β = 0.194, P = .001) at follow-up. Free T did not predict dysglycaemia. In MLWH, dysglycaemia prevalence at follow-up was 12% (n = 10). Neither baseline SHBG nor free T were associated with incident dysglycaemia and glucose metabolism parameters in MLWH. Conclusion: SHBG levels predict the development of dysglycaemia in middle-aged African men but do not exhibit the same predictive value in MLWH. | |
dc.description.sponsorship | South African Medical Research Council (SAMRC). | |
dc.description.sponsorship | UK Medical Research Council (UK MRC). | |
dc.description.sponsorship | GSK Africa Non-Communicable Disease Open Lab (grant project number ES/N013891/1). | |
dc.description.sponsorship | South African National Research Foundation (grant number UID:99108). | |
dc.description.submitter | PM2024 | |
dc.faculty | Faculty of Health Sciences | |
dc.identifier | 0000-0001-7124-3788 | |
dc.identifier.citation | Seipone, I. D., Mendham, A. E., Storbeck, K. H., Oestlund, I., Kufe, C. N., Chikowore, T., Masemola, M., Crowther, N. J., Kengne, A. P., Norris, S., Olsson, T., Brown, T., Micklesfield, L. K., & Goedecke, J. H. (2024). SHBG, Free Testosterone, and Type 2 Diabetes Risk in Middle-aged African Men: A Longitudinal Study. Journal of the Endocrine Society, 8(8), bvae129. https://doi.org/10.1210/jendso/bvae129 | |
dc.identifier.issn | 2472-1972 (online) | |
dc.identifier.uri | https://hdl.handle.net/10539/40058 | |
dc.journal.title | Journal of the Endocrine Society | |
dc.publisher | Oxford University Press | |
dc.relation.ispartofseries | Vol. 8; No. 8 | |
dc.rights | © The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. | |
dc.school | School of Clinical Medicine | |
dc.subject | Free testosterone | |
dc.subject | Sex hormone-binding globulin | |
dc.subject | Dysglycaemia | |
dc.subject | Type 2 diabetes | |
dc.subject | Africa | |
dc.subject.other | SDG-3: Good health and well-being | |
dc.title | SHBG, free testosterone, and Type 2 Diabetes risk in middle-aged African men: a longitudinal study | |
dc.type | Article |