Effect of repeated fever on growth in young guinea pigs

Madu, Scholastica Chinyere
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Repeated infection in early life can induce malnutrition and growth impairment due to the insufficiency of nutrients required to meet the increasing need for nutrients of a growing child, for growth. Infection causes an increase in metabolism and rate of tissue breakdown with a resultant need for extra nutrient intake. The aim of this study was to determine the effect of repeated fever on growth in young guinea pigs. Ten guinea pigs were studied from birth to approximately 60 days of age. At weaning age, guinea pigs were implanted with telemeters to measure body temperature. Then the guinea pigs were grouped into: An experimental group (n=5) receiving muramyl- dipeptide (MDP), and a control group (n=5) receiving normal saline injections. Eight injections per animal were given over the experimental period. Body weights of all animals were measured every 4 days while food intake was measured daily
A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science of Medicine (MSc Med).