Growth regulation by heparin in the vascular wall

dc.contributor.authorKarnovsky, Morris, John
dc.date.accessioned2018-10-15T10:50:46Z
dc.date.available2018-10-15T10:50:46Z
dc.date.issued1983-06-10
dc.descriptionA Thesis Submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg in fulfillment of the requirements for the Degree of Doctor of Science in Medicine Boston, U.S.A. 1983en_ZA
dc.description.abstractVascular smooth muscle proliferation follows upon endothelial injury, and is thought to be an early component in the pathogenesis of atherosclerosis, and a possible noxious consequence of vascular surgery. We have shown that heparin suppresses vascular smooth muscle proliferation iri vivo and in vitro. The inhibitory effect is specific for heparin, and not other anions, and is not related to the antithrombin III binding activity of heparin. It is dependent on the size of the molecule, (hexasaccharidees or smaller being ineffective), and O-sulfation, but not N-sulfationen_ZA
dc.description.librarianIT2018en_ZA
dc.identifier.urihttps://hdl.handle.net/10539/25806
dc.language.isoenen_ZA
dc.subject.meshHeparin
dc.subject.meshIn Vitro Techniques
dc.subject.meshMuscle, Smooth, Vascular
dc.titleGrowth regulation by heparin in the vascular wallen_ZA
dc.typeThesisen_ZA
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