Novel methodology for the synthesis of xanthones

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dc.contributor.authorNaidoo, Jeremy Morgan
dc.date.accessioned2009-10-15T09:03:42Z
dc.date.available2009-10-15T09:03:42Z
dc.date.issued2009-10-15T09:03:42Z
dc.description.abstractIn this MSc, novel methodology for the synthesis of xanthones and related compounds was discovered. It was found that treatment of (1,4-dimethoxynaphthalen-2-yl)(2- hydroxyphenyl)methanone with ceric ammonium nitrate (CAN) resulted in the formation of 12a-methoxy-5H-benzo[c]xanthene-5,7(12aH)-dione as the product. The structure was confirmed by X-ray crystallography. Exposure of a related compound (2,5-dimethoxyphenyl)(2-hydroxyphenyl)methanone to CAN afforded 2-methoxy-9H-xanthen-9-one as the major product with 4amethoxy- 2H-xanthene-2,9(4aH)-dione formed as the minor product. This reaction sequence has opened a new door for research into xanthone synthesis at the University of the Witwatersranden_US
dc.identifier.urihttp://hdl.handle.net/10539/7360
dc.language.isoenen_US
dc.titleNovel methodology for the synthesis of xanthonesen_US
dc.typeThesisen_US
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