Outcomes of women treated with chemotherapy for ovarian cancer at CMJAH

Simple item page
dc.contributor.authorMolebatsi, Justin Boitumelo I
dc.date.accessioned2019-08-28T10:53:51Z
dc.date.available2019-08-28T10:53:51Z
dc.date.issued2017
dc.descriptionA research report submitted to the University of the Witwatersrand in fulfillment of the Master of Medicine Degree, Faculty of Health Sciences, 2017en_ZA
dc.description.abstractBackground Ovarian cancer remains an important cause of mortality in women worldwide. It is the leading cause of death from gynaecological cancers. Worldwide, it is diagnosed in more than 200 000 women annually and is responsible for over 125 000 deaths. In Southern Africa, it is estimated to contribute 3.3% of the total cancer mortality figures in women. The aim of this study was to review the 2 year recurrence free survival for women treated with chemotherapy for ovarian cancer in a South African tertiary care hospital. Methods This was a retrospective cohort of women with primary ovarian cancer treated with chemotherapy at the Charlotte Maxeke Johannesburg academic hospital between 2010 and 2014. Data were extracted from patient records using a standardized data extraction tool. Data was analysed using the STATA Software (StataCorp LP, USA). Precision was managed by using 95% confidence intervals. Results This study showed a 33.78% overall recurrence-free survival at 2 years. The association between surgical stage at presentation with recurrence status at 2 years showed no statistical significance (Pearson chi2(18) = 26.6848 P = 0.085). The difference in outcomes between patients treated with adjuvant chemotherapy and neo-adjuvant chemotherapy did not reach statistical significance (Pr = 0.157) Conclusion Despite extensive surgery and platinum based chemotherapy, this study demonstrates that prognosis for patients with advanced ovarian cancer remains poor with only a third of patients surviving recurrence-free at 2 years follow upen_ZA
dc.description.librarianMT 2019en_ZA
dc.format.extentOnline resource (38 leaves)
dc.identifier.citationMolebatsi, Justin Boitumelo Ishmael, (2018) Outcomes of women treated with chemotherapy for ovarian cancer at CMJAH, University of the Witwatersrand, Johannesburg, https://hdl.handle.net/10539/27912
dc.identifier.urihttps://hdl.handle.net/10539/27912
dc.language.isoenen_ZA
dc.subject.lcshChemotherapy
dc.subject.lcshCancer--Treatment--Complications
dc.titleOutcomes of women treated with chemotherapy for ovarian cancer at CMJAHen_ZA
dc.typeThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Outcomes of women treated with chemotherapy for Ovarian Cancer at CMJAH. PDF.pdf
Size:
821.13 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
ETD Collection