The effect of a ketogenic diet versus a high-carbohydrate, low-fat diet on sleep, cognition, thyroid function, and cardiovascular health independent of weight loss: study protocol for a randomized controlled trial

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dc.contributor.authorIacovides, Stella
dc.contributor.authorMeiring, Rebecca M.
dc.date.accessioned2024-12-19T09:54:32Z
dc.date.available2024-12-19T09:54:32Z
dc.date.issued2018-01
dc.description.abstractBackground: Many physiological health benefits observed after following a ketogenic diet (KD) can be attributed to the associated weight loss. The KD has become more prominent as a popular health choice, not only in obese/ overweight individuals, but also in healthy adults. The study aims to determine the effects of a KD, independent of weight loss, on various aspects of physiological health including: sleep, thyroid function, cognition, and cardiometabolic health. The study will also aim to determine whether a change in basal metabolic rate may be associated with any changes observed. Methods: Twenty healthy men and women between 18 and 50 years of age will take part in this study. In a randomized controlled, cross-over design, participants will follow two isocaloric diets: a high-carbohydrate, low-fat diet (55% CHO, 20% fat, 25% protein) and a KD (15% CHO, 60% fat, 25% protein). Each dietary intervention will last for a minimum of 3 weeks, with a 1-week washout period in between. Before and after each diet, participants will be assessed for sleep quality, cognitive function, thyroid function, and basal metabolic rate. A blood sample will also be taken for the measurement of cardio-metabolic and immune markers. Discussion: The present study will help in understanding the potential effects of a KD on aspects of physiological health in healthy adults, without the confounding factor of weight loss. The study aims to fill a significant void in the academic literature with regards to the benefits and/or risks of a KD in a healthy population, but will also explore whether diet-related metabolic changes may be responsible for the changes observed in physiological health.
dc.description.sponsorshipFaculty of Health Sciences’ Seed Funding for Research, University of the Witwatersrand, Johannesburg.
dc.description.sponsorshipMovement Physiology Research Laboratory, University of the Witwatersrand, Johannesburg.
dc.description.sponsorshipBrain Function Research Group, University of Witwatersrand, South Africa.
dc.description.submitterPM2024
dc.facultyFaculty of Health Sciences
dc.identifier0000-0003-2807-9139
dc.identifier0000-0002-8472-4940
dc.identifier.citationIacovides, S., Meiring, R.M. The effect of a ketogenic diet versus a high-carbohydrate, low-fat diet on sleep, cognition, thyroid function, and cardiovascular health independent of weight loss: study protocol for a randomized controlled trial. Trials 19, 62 (2018). https://doi.org/10.1186/s13063-018-2462-5
dc.identifier.issn1745-6215 (online)
dc.identifier.other10.1186/s13063-018-2462-5
dc.identifier.urihttps://hdl.handle.net/10539/43390
dc.journal.titleTrials
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofseriesVol.19; No. 62
dc.rights© The Author(s). 2018 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
dc.schoolSchool of Physiology
dc.subjectHigh-fat
dc.subjectLow-carbohydrate
dc.subjectKetogenic diet
dc.subjectMetabolism
dc.subjectCognition
dc.subjectThyroid function
dc.subjectSleep
dc.subjectHealthy participants
dc.subject.otherSDG-3: Good health and well-being
dc.titleThe effect of a ketogenic diet versus a high-carbohydrate, low-fat diet on sleep, cognition, thyroid function, and cardiovascular health independent of weight loss: study protocol for a randomized controlled trial
dc.typeArticle
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