The rate and risk factors for local recurrence of phyllodes tumours in a South African population
dc.contributor.author | Spinks, Janice | |
dc.date.accessioned | 2020-10-15T11:22:12Z | |
dc.date.available | 2020-10-15T11:22:12Z | |
dc.date.issued | 2019 | |
dc.description | A research report submitted in fulfilment of the requirement for the degree Masters in Medicine in Surgery to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2019 | en_ZA |
dc.description.abstract | Background: Phyllodes tumours are rare fibroepithelial neoplasms of the breast. The dilemma with phyllodes tumours is their tendency to local recurrence. This retrospective review of phyllodes tumours in a South African population aims to describe the most common histological and clinical features, and describe the clinical and histological risk factors for local recurrence. Methods: All histological reports of patients diagnosed with a phyllodes tumour after surgery at the University of the Witwatersrand Anatomical Pathology Laboratories in Johannesburg were assessed from 1 January 2005 to 30 June 2016. Clinical and histological parameters were analysed. Results: Over the study period, 185 patients were identified. The median age of the patients was 42 years. There were 89 (48.1%) patients with a benign tumour, 34 (18.4%) with a borderline tumour and 62 (33.5%) with a malignant tumour. The size of the tumours ranged from 11 to 460mm, with a median of 85.0mm 79.6 SD. Breast conserving surgery (BCS) was performed on 64.3% of patients and 35.7% of patients had a mastectomy. There was an overall local recurrence rate of 3.78% (2.2% for benign and 8.1% for malignant tumours). No clinical or histological factors, including margin status, were found to significantly predict local recurrence. Most recurrences (71.4%, n=5) occurred within the first two years. Conclusion: Our study did not find any predictors of local recurrence, but we provide further support to the recent suggestion of revising the common practice of wide local excision with a 1cm margin, to an excision with negative margins combined with close follow-up for two years. | en_ZA |
dc.description.librarian | TL (2020) | en_ZA |
dc.faculty | Faculty of Health Sciences | en_ZA |
dc.format.extent | Online resource (62 leaves) | |
dc.identifier.citation | Spinks, Janice (2019) The rate and risk factors for local recurrence of Phyllodes tumours in a South African population, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/29855> | |
dc.identifier.uri | https://hdl.handle.net/10539/29855 | |
dc.language.iso | en | en_ZA |
dc.subject.mesh | Breast Disease | |
dc.subject.mesh | Cancer--Imaging | |
dc.title | The rate and risk factors for local recurrence of phyllodes tumours in a South African population | en_ZA |
dc.type | Thesis | en_ZA |
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