The rate and risk factors for local recurrence of phyllodes tumours in a South African population

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dc.contributor.authorSpinks, Janice
dc.date.accessioned2020-10-15T11:22:12Z
dc.date.available2020-10-15T11:22:12Z
dc.date.issued2019
dc.descriptionA research report submitted in fulfilment of the requirement for the degree Masters in Medicine in Surgery to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2019en_ZA
dc.description.abstractBackground: Phyllodes tumours are rare fibroepithelial neoplasms of the breast. The dilemma with phyllodes tumours is their tendency to local recurrence. This retrospective review of phyllodes tumours in a South African population aims to describe the most common histological and clinical features, and describe the clinical and histological risk factors for local recurrence. Methods: All histological reports of patients diagnosed with a phyllodes tumour after surgery at the University of the Witwatersrand Anatomical Pathology Laboratories in Johannesburg were assessed from 1 January 2005 to 30 June 2016. Clinical and histological parameters were analysed. Results: Over the study period, 185 patients were identified. The median age of the patients was 42 years. There were 89 (48.1%) patients with a benign tumour, 34 (18.4%) with a borderline tumour and 62 (33.5%) with a malignant tumour. The size of the tumours ranged from 11 to 460mm, with a median of 85.0mm  79.6 SD. Breast conserving surgery (BCS) was performed on 64.3% of patients and 35.7% of patients had a mastectomy. There was an overall local recurrence rate of 3.78% (2.2% for benign and 8.1% for malignant tumours). No clinical or histological factors, including margin status, were found to significantly predict local recurrence. Most recurrences (71.4%, n=5) occurred within the first two years. Conclusion: Our study did not find any predictors of local recurrence, but we provide further support to the recent suggestion of revising the common practice of wide local excision with a 1cm margin, to an excision with negative margins combined with close follow-up for two years.en_ZA
dc.description.librarianTL (2020)en_ZA
dc.facultyFaculty of Health Sciencesen_ZA
dc.format.extentOnline resource (62 leaves)
dc.identifier.citationSpinks, Janice (2019) The rate and risk factors for local recurrence of Phyllodes tumours in a South African population, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/29855>
dc.identifier.urihttps://hdl.handle.net/10539/29855
dc.language.isoenen_ZA
dc.subject.meshBreast Disease
dc.subject.meshCancer--Imaging
dc.titleThe rate and risk factors for local recurrence of phyllodes tumours in a South African populationen_ZA
dc.typeThesisen_ZA
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