Investigation of the immune-modulatory effects of erythromycin

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dc.contributor.authorFernandes, Antonio, Celestino
dc.date.accessioned2018-10-11T10:47:49Z
dc.date.available2018-10-11T10:47:49Z
dc.date.issued1986-06-20
dc.descriptionA Dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg, for the Degree of Master of Science (MED). JOHANNESBURG, 1986en_ZA
dc.description.abstractThe Literature Review covers the immunosuppressive and immunopotentiating properties of antibiotics on the immune system and the effects these could have on the resolution of an infection. The possible pathogenic mechanisms of C. albicans are also reviewed in this section. The experimental section shows that pre-treatment of mice with erythromycin increases the mean survival time following intraperitoneal inoculation of C. albicans. It was shown that erythromycin enhanced lymphocyte transformation and PMNL migration in both in-vivo and in-vitro situations. These enhanced immunological components probably caused improved survival times in the aforementioned animal experiments. To investigate the effects of oral administration of erythromycin on in-vivo PMNL migration in adult volunteers a new quantitative test which could only be applied to humans was developed and is described in detail. Using this method preliminary data were obtained which show that erythromycin increases PMNL migration in-vivo.en_ZA
dc.description.librarianIT2018en_ZA
dc.identifier.urihttps://hdl.handle.net/10539/25754
dc.language.isoenen_ZA
dc.subject.meshErythromycin
dc.subject.meshIn Vitro Techniques
dc.subject.meshNeutrophils
dc.titleInvestigation of the immune-modulatory effects of erythromycinen_ZA
dc.typeThesisen_ZA
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