A comparison between atropine and cyclopentolate in cycloplegic refraction in children

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dc.contributor.authorKisten, Divashini
dc.date.accessioned2020-09-14T07:58:18Z
dc.date.available2020-09-14T07:58:18Z
dc.date.issued2019
dc.descriptionA research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of Medicine. Johannesburg, July 2019en_ZA
dc.description.abstractBackground: Cycloplegic refraction is a reliable procedure for obtaining an accurate refraction in children. Atropine is considered the gold standard, however, it does not have the properties of an ideal cycloplegic agent. Theoretically, cyclopentolate is the preferred agent and many have advocated it as an alternative. In the African population where dark irides are common there is insufficient information comparing the two agents, especially so in younger aged children. Objective: To establish if cyclopentolate is as effective as atropine in cycloplegic refraction in dark irides. Method: A prospective, sequential, paired study on patients requiring cycloplegic refraction was conducted. Each patient was refracted after the usage of cyclopentolate. Refraction was then repeated 2 weeks later after using atropine. Results: 40 patients (80 eyes) were refracted with both agents. The mean difference between the agents (atropine – cyclopentolate) was +0,14 DS (95% CI: +0.05 to +0.24; paired t-test; p=0.0027), however, the effect size was small (Cohen’s d=0.35) making it clinically insignificant. No adverse effects were reported with either of the cycloplegic agents. Conclusion: Cyclopentolate is as effective as atropine for cycloplegic refraction in dark irides and can be used as an alternative to atropine for cycloplegic refraction.en_ZA
dc.description.librarianMT 2020en_ZA
dc.facultyFaculty of Health Sciencesen_ZA
dc.format.extentOnline resource (30 leaves)
dc.identifier.citationKisten, Divashini (2019) A comparison between atropine and cyclopentolate in cycloplegic refraction in children, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/29595>
dc.identifier.urihttps://hdl.handle.net/10539/29595
dc.language.isoenen_ZA
dc.subject.meshBronchoscopy
dc.subject.meshAtropine
dc.subject.meshGlycopyrrolate
dc.titleA comparison between atropine and cyclopentolate in cycloplegic refraction in childrenen_ZA
dc.typeThesisen_ZA
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