A retrospective study of the epidemiology and histological subtypes of ovarian epithelial neoplasms at Charlotte Maxeke Johannesburg academic hospital

Pillay, Lusela
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Background: Epithelial ovarian neoplasms constitute most ovarian tumours and are the most common malignant ovarian neoplasm. They are the eighth leading cause of cancer deaths worldwide. This study evaluated the epidemiology and histological subtypes of epithelial ovarian neoplasms at a single institution. Methods: This retrospective, quantitative analysis evaluated 123 epithelial ovarian neoplasms between 2013-2017 and classified them according to age, biological behaviour and histological subtype. Results: Of 123 cases, 64 (52.0%), tumours were benign, 30 (24.4%) were atypical proliferative tumours and 29 (23.6%) tumours were malignant. Serous cystadenoma was the most common benign tumour (42.2%). Atypical proliferative mucinous neoplasms were the most common atypical proliferative tumour (50.0%). High-grade serous carcinoma was the most common carcinoma (58.6%). Patients presented at an older age with atypical proliferative tumours and malignant tumours, compared to patients with benign tumours. Conclusion: The current study demonstrated that serous tumours were the most common type of benign and malignant tumours whilst mucinous neoplasms were the commonest subtype of atypical proliferative tumours. These findings are congruent with multiple similar studies. A higher number of atypical proliferative tumours were seen in this cohort in comparison to previous studies. This suggests a need for additional sampling of atypical proliferative tumours, over and above the international standard, in our population, to definitively exclude invasive malignancy. This study also demonstrated the histological progression of benign serous and mucinous tumours to atypical proliferative tumours and low-grade serous carcinoma and mucinous carcinoma, respectively, which supports the stepwise tumour progression model of these tumours.
A research report in "submissible format", in submission in partial fulfilment of the requirements for the degree of Masters of Medicine in the branch of Anatomical Pathology to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2022