The diagnostic accuracy of the HIV 1/2/subtype O Tri-line HIV rapid test in comparison to ELISA

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dc.contributor.authorManenzhe, Shumani Charlotte
dc.date.accessioned2018-08-15T11:38:09Z
dc.date.available2018-08-15T11:38:09Z
dc.date.issued2018
dc.descriptionA research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of Dentistry. Johannesburg, 2018.en_ZA
dc.description.abstractBackground: Accurate HIV diagnosis is critical and can be life-saving. A Rapid Test (RT) is considered key to HIV prevention and management. Some studies have found RT to be comparable with ELISA whilst others have reported on lower sensitivity. Aim and study design: The aim of this retrospective comparative descriptive study was to evaluate the sensitivity and specificity of the Tri-line HIV rapid test device in comparison to ELISA on patient records from Wits Oral Health Centre (WOHC) between 2014 and 2016 Method: The study population comprised records of patients older than18 months who had Tri-Line HIV RT and blood drawn for ELISA on the same day. Descriptive analysis of the data was carried out. Results: The sensitivity of Tri-line was 80% (CI: 59-93%) and specificity was 100% (CI: 83-100%). The PPV was 100% (CI: 83-100%) and NPV was 80% (CI: 65-90%). ROC area of 0.9 at 95% CI was determined. Conclusion: Due to a low sample size in this study a definitive conclusion could not be drawn. However on the basis of the results obtained, although the tri-line RT showed lower sensitivity it was shown to be a clinically useful test.en_ZA
dc.description.librarianLG2018en_ZA
dc.identifier.urihttps://hdl.handle.net/10539/25389
dc.language.isoenen_ZA
dc.subjectTri-Line HIV RT
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshHIV
dc.titleThe diagnostic accuracy of the HIV 1/2/subtype O Tri-line HIV rapid test in comparison to ELISAen_ZA
dc.typeThesisen_ZA
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