An evaluation of the efficacy and safety of meprobamate in combination analgesics and the likely economic impact of its withdrawal

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Peter, Amanda, Clare

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South Africa has the highest number of registered medicine containing meprobamate in combination analgesics and is the only country that markets a combination that includes paracetamol, caffeine and codeine. In November 1998 the \medicine Control Council issued a circular (11/98) to the pharmaceutical industry requesting evidence that meprobamate contributes meaningfully to the therapeutic effect in combination analgesics and asked for comment on the risk-benefit ratio

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfilment of the requirements for the degree of Master of Science ( Medicine ) in pharmaceutical affairs Johannesburg

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