Design of a gastrofloatable and gastroadhesive drug delivery system for narrow absorption window and low bioavailable drugs
Date
2011-10-27
Authors
Murphy, Caragh Synnøve
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Abstract
Electro-spinning of polymers is a unique technology which produces very fine fibres using
electrostatic repulsive forces obtained from applying an electrical potential to a liquid. The
resultant fibres have much smaller diameters in comparison with fibres obtained using
different methods. Electro-spun fibres have found application in many and varied fields
such as drug and gene delivery, tissue engineering, wound dressing, electronics, filtration
as well as absorption and adsorption. This review will cover the various processing
parameters which play a role in electro-spinning, including the applied voltage, solution
flow rate, solution viscosity, solvents, solution conductivity, capillary-to-collector distances
and the influence of surfactants. A main focus will be on the application of electro-spun
fibres in drug delivery, where researchers have already investigated the use of these
fibres in transdermal delivery systems, long-term implants and grafts. Different methods of
drug incorporation will be discussed as well as numerous polymers which have been
successfully utilised in this field, including cellulose acetate, poly(ε-caprolactone),
poly(ethylene oxide), poly(vinyl alcohol), gelatin, poly(d,l-lactide-co-glycolide), poly(lactic
acid), poly(l-lactic acid), polyurethane, poly(ethylene-co-vinyl acetate), poly(ethylene
glycol), and poly(acrylic acid).
Keywords: Electro-spinning, drug delivery, electrospun fibres, electrospun scaffolds,
Parameters.