3. Electronic Theses and Dissertations (ETDs) - All submissions
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Item Some aspects of experimental and human phenacetin nephritis(1963-11) Abrahams, CyrilModern pathology is forced to deal more and more with changes brought about by modern therapy on the one hand and by the abuse of drugs by the laity on the other ^ New diseases have been added, others altered. Skin allergies, collagen diseases, frightening foetal abnormalities due to thalidomide, peptic ulceration with cortison therapy are but a few of the end results of the abuse of the numerous pharmaceutical substances available with or without prescription to the public. To this list may be added the nephrotoxic effects of phena- cetin.Item Skeletal muscle damage repair and adaptation to uphill and downhill running in humans(1994) Krafft, IngridExtensive disruption of muscle fibres has been shown to occur after short term eccentric exercise where high mechanical forces are generated. This study tested whether downhill running acts as a stimulus for inducing eccentric damage, and results in greater muscle damage and deterioration in muscular performance than an equal workload of uphill running. The study aimed at determining whether an adaptation or training eflect takes place such that the muscle is more resistant to the damaging effects of a repeated bout of the same exercise. In addition, the study aimed at determining whether the lower muscle volumes and forces of muscular contractions in females compared to males, makes females less susceptible to the damaging effects of eccentric contraction.