3. Electronic Theses and Dissertations (ETDs) - All submissions
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Item Reticuloendothelial ferritin messenger RNA in inflammatory states(1989) Lapinsky, Stephen. E.Ferritin is an iron storage protein, made up of heavy (H) and light (L) subunits. Ferritin synthesis is regulated at a post transcriptional level by iron, which induces a redistribution of ferritin mRNA from a free cytoplasmic pool to polyribosomes. Inflammatory states influence iron metabolism, causing a decrease in serum iron levels associated with an increase in reticuloendothelial ferritin synthesis and iron storage.Item Factors involved in the handling of iron by the reticulo-endothelial system(1972) Lipschitz, D. A.For centuries iron was regarded as a source of health and vigour, and it has been known for at least 200 years that it is a component of blood and effective in the treatment of chlorosis. However, its metabolism remained largely a mystery until the advent of radioactive iron isotopes in 1938. Since then most of the major pathways of this metal into, through and out of the body have been elucidated. In addition the functions which it subserves have been partially characterized.Item Ferritin as an iron transport protein ferritin uptake and iron ultilisation by guinea pig placenta(1990) Lamparelli, Rosario D. V.The guinea pig clears circulating tissue ferritin in a manner different from other mammals. Previous work in man and in rats has shown that injected tissue ferritin is removed from the plasma predominantly by the liver; however, in the guinea pig it is cleared predominantly by red cell precursors and furthermore, the ferritin iron is utilised directly for haem synthesis. During pregnancy, the foeto-placental complex also has a high requirement for iron.