3. Electronic Theses and Dissertations (ETDs) - All submissions
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Item Serum resistance and outer membrane proteins of haemophilus ducreyi(1990-12) Elias, Eric.The pathogenicity of haemophilus ducreyi, the etiological agent of chancroid is poorly understood. Although h.ductreyi appears not to invade the bloodstream, resistance to lysis by normal human serum may allow prolonged multiplication of the organism within tissues. The determinants of serum resistance, however, remain to be elucidated and could include a number of bacterial surface components including outer membrane proteins (OMPs) and lipopolysaccharideItem Serum resistance and lipopolysaccharide of haemophilus ducreyi(1990-02) Jardine, Jocelyn. LeonieThe pathogenesis of Haemophilus ducreyi, the aetiological agent of chancroid' is poorly understood. An ability to resist killing by pooled normal human serum (PNHS) appears to contribute to the virulence of several Gram-negative bacteria, influenced by their lipopolysaccharide (LPS) in certain cases. The aim of this investigation is to measure the degree of serum resistance in clinical strains of H. ducreyi, and to determine whether their LPS plays a role in this serum resistance.Item Characterization of genes conferring v factor independence in haemophilus parainfluenzae and haemophilus ducreyi(1994-12-18) Windsor, Helen. MarieHaemophilus influenzae and Haemophilus parainfluenzae are obligate human parasites that form part of the flora of the mucous membranes. They are normally present in the mouth and upper respiratory tract of healthy individuals. H. influenzae is known as a major pathogen in children while H. parainfluenzae is an opportunistic pathogen which is also found in the urogenital tract. H. ducreyi, however, has only been isolated from genital ulcers in patients suffering from chancroid. The various species of the genus Haemophilus are characterised by their requirements for two growth factors, X factor or haemin and V factor or nicotinamide adenine dinucleotide (NAD).Item Characterisation of plasmids conferring ampicillin resistance in South African isolates of haemophilus ducreyi(1996-03-27) Leong, May-Yong GeraldineFifty-two strains of Haemophilus ducreyi from various geographic regions of southern Africa (Botswana, Lesotho, Namibia, Gauteng, Natal and Transkei) isolated between 1988 to 1994 were tested for susceptibilities to five antimicrobial agents and characterized according to their plasmid content and ampicillin- resistance genes.