3. Electronic Theses and Dissertations (ETDs) - All submissions
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Item Infections and malignancies associated with cryptococcal antigenemia among patients with CD4 counts ≤100 cells/mm3(2020) Ratau-Dintwe, Mmabatho Ngoananoka PortiaItem A prospective, observational study of cryptococcal infection and clinical and ophthalmologic outcomes.(2006-10-27) Ehlers, Natalia. Lydia. Maria.Cryptococcosis is a serious fungal infection. Neurological, pulmonary and cutaneous complications are more commonly found in the immunocompetent host. Long-term ocular sequelae have not been well investigated.Item Cryptococcal antigenaemia in patients hospitalised with community acquired pneumonia at Chris Hani Baragwanath Academic Hospital(2014-08-27) Korb, AnneliBackground Cryptococcus is a life-threatening opportunistic infection; data is limited regarding early infection. Treatment of cryptococcal antigenaemia may impact on disease progression. Screening those most at risk for cryptococcal antigenaemia is necessary to be cost effective. The prevalence of cryptococcal antigenaemia in patients hospitalised with community acquired pneumonia (CAP) at Chris Hani Baragwanath Academic Hospital (CHBAH) was evaluated. Methods 200 patients admitted to CHBAH with presumed CAP were enrolled. Clinical and laboratory data were collected and a Cryptococcal Lateral Flow Immunoassay was done on whole blood. Results Of the 200 patients, 185 (92.5%) were HIV-infected. Amongst the HIV-infected group, the median CD4 cell count was 47 cells/mm3 and 111 subjects (60%) had a CD4 cell count < 100 cells/mm3. The prevalence of cryptococcal antigenaemia was 0.5% (CI 0.01-2.75). Conclusion The prevalence of cryptococcal antigenaemia amongst inpatients with CAP was low. Routine screening of this group would not be cost-effective.