3. Electronic Theses and Dissertations (ETDs) - All submissions

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Author: search.filters.author.Richardt, DeniseSubject: search.filters.subject.Pharmacokinetics

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    The effects of miglitol on the pharmacokinetics of phenytoin in healthy volunteers
    (1996-12-22) Richardt, Denise
    The interaction between miglitol, an a-glucosidase inhibitor used as an adjunct therapy in diabetes, and phenytoin, an anticonvulsant primarily used in the treatment of epilepsy, was studied over 26 days. Twenty-four healthy male volunteers took part in a placebo controlled, double blind, cross-over study in two phases, to determine the effects of multiple 100mg doses of miglitol on a single 400mg dose of phenytoin sodium. Miglitol or placebo was administered three times daily from Day 1 to Day 5. Phenytoin was administered as a single dose on Day 3 of each phase, after which blood samples were taken at regular intervals. A washout period of 14 days separated the two phases.
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