ETD Collection

Permanent URI for this collectionhttps://wiredspace.wits.ac.za/handle/10539/104


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  • Item
    Molecular biological characterisation of the novel Rifampicin inactivation mechanism in Nocardioform bacteria
    (1996) Andersen, Susan Jean
    Rifampicin is one of the major antibiotics used in the treatment of Mycobacterium tuberculosis. This organism causes tuberculosis. Other related nocardioform bacteria which include the Rhodococci are opportunistic pathogens in AIDS patients. These organisms cause tuberculosis-like disease and are currently treated with rifampicin and other drugs. The presence of a low level rifampicin resistance mechanism was identified in seven rhodococcal strains and five other related and unrelated bacteria. Abbreviated Abstract. Open document to view full version]
  • Item
    Investigating the genes for bile acid metabolism in nocardioform bacteria
    (1991) Brown, Sharon Teresa
    Nocardioform bacteria were studied for their ability to interconvert bile acids. From the studies of utilisation and resistance curves, the most suitable donor and recipient strains for complementary gene cloning, were Arthrobacter oxydans strain C1 and Rhodococcus erythropolis strain ATCC 4217-1 respectively. [Abbreviated Abstract. Open document to view full version]