ETD Collection

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Subject: search.filters.subject.Lupus Erythematosus, Systemic

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    Systemic lupus erythematosus: the Johannesburg experience
    (1986) Morrison, Richard C. A.
    This study is a predominantly retrospective analysis of patients in Johannesburg who presented with Systemic Lupus Erythematosus at 12 years of age or older. Johannesburg is situated at high altitude and has a high level of ultraviolet light irradiation/ a known exacerbating factor of the disease. This study draws comparisons with reported disease characteristics of lupus patients elsewhere in the world. In addition/ it examines differences in the clinical manifestations of the disease amongst the principle South African racial groups.
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    The prevalence of cutaneous lupus manifestations in patients diagnosed with Systemic Lupus Erythematosus (SLE) attending the Chris Hani Baragwanath academic hospital rheumatology outpatient clinic
    (2017) Koch, Karen
    Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder. The skin is affected in up to 85% of cases. Aims The objective of this study was to determine the prevalence and spectrum of both specific and non-specific cutaneous findings in SLE patients attending Chris Hani Baragwanath Academic Hospital. Methods A retrospective record review of 298 patients meeting the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria for SLE. Cutaneous findings were divided into LE- specific disease (Cutaneous Lupus Erythematosus) and LE-nonspecific findings. The Lupus Severity Index (LSI) was calculated according to the Bello et al. Results The mean (SD) age at presentation was 35 years (11.8) and the female: male ratio was 13:1. Eighty-three percent of patients had cutaneous findings and CLE affected 76.1% of patients. Discoid Lupus Erythematosus (DLE) was the commonest form of CLE followed by Acute Cutaneous Lupus Erythematosus (ACLE). Patients with CLE had a significantly better Lupus Severity Index (LSI) (5.7 vs 6.1; p=0.001). Those patients with Chronic Cutaneous Lupus Erythematosus (CCLE) had a better LSI than those with ACLE (6.07 vs 6.5; p=0.001). Conclusion The skin was the single most commonly affected organ system. DLE, both localised and generalised, was very common in patients with SLE, occurring more frequently than ACLE. Patients with CLE had a better LSI than those without.
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    The prevalence of anti-C1q antibodies in black South Africans with systemic lupus erythematosus and their clinical significance
    (2013-04-08) Makda, Mohamed Amin
    INTRODUCTION: Several studies have shown an association of anti-C1q antibodies (abs) with systemic lupus erythematosus (SLE) nephritis and disease activity. The aim of this study is to determine the relevance of the anti-C1q abs and the C1q levels, in Black South Africans with SLE and their relevance to disease activity and/or organ damage, specifically renal disease. METHODS: Serum anti-C1q abs and C1q levels were measured in 96 SLE patients who were also assessed for disease activity, using the SELENA Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and organ damage as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC) Damage Index. Furthermore patients were assessed for the presence of an active urine sediment as evidenced by otherwise unexplained proteinuria, haematuria or cellular casts. Serum anti-C1q abs was measured by a commercial Elisa kit and serum C1q by immunoelectrophoresis. RESULTS: Of the 96 patients; the majority, 87 were female (90.65%), with a mean (SD) age and disease duration (SD) of 38.1 (13.0) years and 4.2 (4.4) years respectively. An active urine sediment was found in 21 (21.88%) patients. Elevated anti-C1q abs were present in 12 (12.50%) of the patients and 7 (14.29%) of the patients with renal involvement. Serum anti-C1q abs levels correlated significantly with SELENA SLEDAI scores (p=0.004, r =0.41).Anti-C1q abs levels were significantly higher in patients with an active urine sediment (p= 0.007). C1q levels were decreased in 17/96 (17.71%) patients and 11/49 (22.45%) patients with renal involvement. No associations with any other clinical features were observed. CONCLUSION: The findings indicate that in Black South Africans with SLE, although elevated anti-C1q abs levels were present in only a small minority of patients, the abs were associated with SLE global activity as determined by the SELENA SLEDAI and to the presence of an active urine sediment. These findings suggest that anti-C1q abs are a potential bio-marker of disease activity, especially active renal disease.