ETD Collection

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Subject: search.filters.subject.Iron Metabolism Disorders

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    Cellular iron metabolism in haemochromatotic macrophages
    (1995) Ickinger, Claudia
    HLA-linked haemochromatosis is the result of an inborn error of metabolism inherited as an autosomal recessive gene, closely linked to the HLA locus on chromosome six. In this condition iron absorption is inappropriately high leading to iron overload. Integral to the pathogenesis of this disorder and in contrast to other causes of iron overload, is the relatively modest accumulation of iron within cells of both the small intestine and the reticuloendothelial system and the excessive deposition of iron in parenchymal cells of the liver and other organs. This observation has led to the suggestion that the primary defect(s) could be present in either the gut, the liver, the reticuloendothelial system or all three. Abnormalities in iron uptake by cells, iron transport through and between cells and iron storage in cells have all been suggested as possible mechanisms responsible for the abnormal absorption and distribution of iron in haemochromatosis. Malfunction of the iron transport protein transferrin or its receptor could be responsible for abnormal distribution and iron loading while an abnormality of ferritin iron storage could explain why some cells appear to be unable to store iron and others are iron overloaded.
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    Iron Metabolism: a series of publications on various aspects of iron metabolism.
    (1964-10) Bothwell, T. H.
    ffiy interest in iron metabolism was initially aroused in 1948 by a young patient with idiopathic haemochromatosis who was admitted to Professor Elliott*© ward while I was serving my medical internship, With the support of the Council for Scientific and Industrial Research it was possible to carry out radioisotopic studies on this patient and over the next four years a number of other subjects with the same disease ware investigated. As the study continued, attention was also directed to the siderosis which is so common in adult Bantu, and to the Iron overload which results from the administration of repeated blood transfusions to subjects with refractory anaemias.
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    Aspects of iron metabolism in infection, inflammation and neoplasia. Vol. 2
    (1987) Baynes, Roy, Dennis
    This thesis evaluates several aspects of iron metabolism in the setting of infection, inflammation and neoplasia. The work is divided into three major sections. The first investigate the changes in iron metabolism that occur as part of the acute phase response to infection, inflammation and neoplasia. The second section evaluates the normal and pathological biology of the iron-binding glycoprotein lactoferrin. IN the third section the iron transport protein transferrin is investigated in relation to its interaction with the macrophage, a cultured malignant hepatoma cell and a cultured malignant ovarian cell.