Browsing by Author "Tinashe Chikowore"
Now showing 1 - 11 of 11
- Results Per Page
- Sort Options
Item The association of menopause with cardiometabolic disease risk factors in lowand middleincome countries A systematic review and metaAnalyses(LIPPINCOTT WILLIAMS & WILKINS) Raylton Chikwati; Tinashe Chikowore; Nasrin Goolam Mahyoodeen; Nicole Jaff; Jaya George; Nigel CrowtherItem The case for precision medicine in the prevention diagnosis and treatment of cardiometabolic diseases in lowincome and middleincome countriesS Misra; A Aguilar-Salinas; Tinashe Chikowore; F Konradsen; Ronald CW Ma; E et alItem Factors associated with frequency of fruit and vegetable consumption among selected subSaharan African populations evidence from the Cardiovascular H3Africa Innovation Resource Project(OXFORD UNIV PRESS) A Okekunle; O Asowata; O Akpa; Adekunle Gregory Fakunle; Tinashe Chikowore; Michele Ramsay; Z Lombard; E et alItem Hepatitis B infection is causally associated with extrahepatic cancers A Mendelian randomization studyAbram Kamiza; Segum Fatumo; Mwiza Singini; Ching-Ching Yeh; Tinashe ChikoworeItem Leveraging information between multiple population groups and traits improves finemapping resolution(NATURE PUBLISHING GROUP) F Zhou; O Soremekun; Tinashe Chikowore; S Fatumo; Inês Barroso; E et alItem A mendelian randomization study of genetic liability to posttraumatic stress disorder and risk of ischemic strokeOpeyemi Soremekun; Clarisse Musanabaganwa; Annette Uwineza; Maddalena Ardissino; Tinashe Chikowore; et al et alItem Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits(2022-05-11) Ananyo Choudhury; Jean-Tristan Brandenburg; Tinashe Chikowore; Dhriti Sengupta; Palwende Romuald Boua; Nigel J. Crowther; Godfred Agongo; Gershim Asik; F. Xavier Gómez-Olivé; Isaac Kisiangani; Eric Maimela; Matshane Masemola-Maphutha; Lisa K. Micklesfield; Engelbert A. Nonterah; Shane A. Norris; Hermann Sorgho; Halidou Tinto; Stephen Tollman; Sarah E. Graham; Cristen J. Willer; AWI-Gen study; H3Africa Consortium; Scott Hazelhurst; Michèle RamsayGenetic associations for lipid traits have identified hundreds of variants with clear differences across European, Asian and African studies. Based on a sub-Saharan-African GWAS for lipid traits in the population cross-sectional AWI-Gen cohort (N = 10,603) we report a novel LDL-C association in the GATB region (P-value=1.56 × 10−8). Meta-analysis with four other African cohorts (N = 23,718) provides supporting evidence for the LDL-C association with the GATB/FHIP1A region and identifies a novel triglyceride association signal close to the FHIT gene (P-value =2.66 × 10−8). Our data enable fine-mapping of several well-known lipid-trait loci including LDLR, PMFBP1 and LPA. The transferability of signals detected in two large global studies (GLGC and PAGE) consistently improves with an increase in the size of the African replication cohort. Polygenic risk score analysis shows increased predictive accuracy for LDL-C levels with the narrowing of genetic distance between the discovery dataset and our cohort. Novel discovery is enhanced with the inclusion of African data.Item Physical Activity and Its Association With Body Mass Index: A Cross-Sectional Analysis in Middle-Aged Adults From 4 Sub-Saharan African Countries(2023-08-17) Monica Mut; Lisa J. Ware; Lisa K. Micklesfield; Michele Ramsay; Godfred Agongo; Palwende R. Boua; Isaac Kisiangani; Ian Cook; Francesc Xavier Go´mez-Olivé; Nigel J. Crowther; Chodziwadziwa Kabudula; Shane A. Norris; Tinashe ChikoworeBackground: This study aimed to explore association of self-reported physical activity domains of work, leisure, and transport-related physical activity and body mass index (BMI) in 9388 adult men and women from the Africa-Wits-INDEPTH partnership for Genomic (AWI-Gen) study in Africa. Africa-Wits-INDEPTH partnership for Genomic is a large, population-based cross-sectional cohort with participants from 6 sites from rural and urban areas in 4 sub-Saharan African countries. Methods: A sex-stratified meta-analysis of cross-sectional data from men and women aged 29–82 years was used to assess the association of physical activity with BMI. Results: Overall, meeting physical activity guidelines of at least 150 minutes per week was associated with 0.82 kg/m2 lower BMI in men (β = −0.80 kg/m2 ; 95% confidence interval [CI], −1.14 to −0.47) and 0.68 kg/m2 lower BMI in women (β = −0.68 kg/m2 ; 95% CI, −1.03 to −0.33). Sex and site-specific differences were observed in the associations between physical activity domains and BMI. Among those who met physical activity guidelines, there was an inverse association between transport-related physical activity and BMI in men from Nanoro (Burkina Faso) (β = −0.79 kg/m2 ; 95% CI, −1.25 to −0.33) as well as work-related physical activity and BMI in Navrongo men (Ghana) (β = −0.76 kg/m2 ; 95% CI, −1.25 to −0.27) and Nanoro women (β = −0.90 kg/m2 ; 95% CI, −1.44 to −0.36). Conclusions: Physical activity may be an effective strategy to curb rising obesity in Africa. More studies are needed to assess the impact of sex and geographic location-specific physical activity interventions on obesity.Item Postprandial glucose variability and clusters of sex hormones liver enzymes and cardiometabolic factors in a South African cohort of African ancestryBontle Masango; Julia Goedecke; Michele Ramsay; Karl-Heinz Storbeck; Lisa Micklesfield; Tinashe ChikoworeItem SHBG Free Testosterone and Type 2 Diabetes Risk in Middleaged African Men A Longitudinal StudyIkanyeng D Seipone; Amy Mendham; Karl-Heinz Storbeck; Imken Oestlund; Clement Kufe Nyuyki; Tinashe Chikowore; Maphoko Masemola; Nigel Crowther; Andre Pascal Kengne; Shane Norris; Lisa Micklesfield; Julia Goedecke; et al et alItem Variability of polygenic prediction for body mass index in Africa(BIOMED CENTRAL LTD) Tinashe Chikowore; Kristi Lall; Lisa Micklesfield; Zane Lombard; Julia Goedecke; Segun Fatumo; Shane Norris; Reedik Magi; Michele Ramsay; Paul W Franks; E et al