Browsing by Author "Michelle Groome"
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Item Clinical presentation and management of childhood intussusception in South AfricaS Cox; Aletha Withers; M Arnold; M Chitnis; C de Vos; Jerome Loveland; Shabir Madhi; E et al; Michelle GroomeItem Estimation of vaccine effectiveness against SARSCoV2associated hospitalization using sentinel surveillance in South AfricaN Chiwandire; Sibongile Walaza; Anne Von Gottberg; Nicole Wolter; Mignonette Du Plessis; Fahima Moosa; Michelle Groome; Jeremy Nel; Ebrahim Variava; H Dawood; Mvuyo Makhasi; L R Feldstein; P Marcenac; E et al; Cheryl CohenItem FUT2 secretor status influences susceptibility to VP4 strainspecific rotavirus infections in South African childrenJaime MacDonald; Michelle Groome; J Mans; N PageItem Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018 a systematic review and modelling studyXin Wang; You Li; Katherine L O'Brien; Shabir Madhi; Marc-Alain Widdowson; Peter Byass; Cheryl Cohen; Michelle Groome; Florette Treurnicht; E et alItem Human MetapneumovirusAssociated Hospitalization in HIV1 Exposed Uninfected and HIV1 Uninfected Children Less Than 5 Years in South AfricaLesego Ramocha; Jeffrey Dorfman; Michelle Groome; Vicky Baillie; Charl Verwey; Marius Laubscher; Martha Nunes; Shabir MadhiItem In utero human cytomegalovirus infection is associated with increased levels of putatively protective maternal antibodies in nonprimary infection evidence for boosting but not protectionJeffrey Dorfman; Sashkia Balla; Jayani Pathirana; Michelle Groome; Shabir Madhi; Penelope MooreItem Incidence of febrile seizures and associated factors in children in Soweto South AfricaNaume Tebeila; Ziyaad Dangor; Shabir Madhi; Clare Cutland; Michelle GroomeItem Mortality in children aged <5 years with severe acute respiratory illness in a high HIVprevalence urban and rural areas of South Africa, 2009–2013(2021-08-12) Oluwatosin A Ayeni; Sibongile Walaza; Stefano Tempia; Michelle Groome; Kathleen Kahn; Shabir A Madhi; Adam L Cohen; Jocelyn Moyes; Marietjie Venter; Marthi Pretorius; Florette Treurnicht; Orienka Hellferscee; Anne von Gottberg; Nicole Wolter; Cheryl CohenBackground: Severe acute respiratory illness (SARI) is an important cause of mortality in young children, especially in children living with HIV infection. Disparities in SARI death in children aged <5 years exist in urban and rural areas. Objective: To compare the factors associated with in-hospital death among children aged <5 years hospitalized with SARI in an urban vs. a rural setting in South Africa from 2009-2013. Methods: Data were collected from hospitalized children with SARI in one urban and two rural sentinel surveillance hospitals. Nasopharyngeal aspirates were tested for ten respiratory viruses and blood for pneumococcal DNA using polymerase chain reaction. We used multivariable logistic regression to identify patient and clinical characteristics associated with in-hospital death. Results: From 2009 through 2013, 5,297 children aged <5 years with SARI-associated hospital admission were enrolled; 3,811 (72%) in the urban and 1,486 (28%) in the rural hospitals. In-hospital case-fatality proportion (CFP) was higher in the rural hospitals (6.9%) than the urban hospital (1.3%, p<0.001), and among HIV-infected than the HIV-uninfected children (9.6% vs. 1.6%, p<0.001). In the urban hospital, HIV infection (odds ratio (OR):11.4, 95% confidence interval (CI):5.4-24.1) and presence of any other underlying illness (OR: 3.0, 95% CI: 1.0-9.2) were the only factors independently associated with death. In the rural hospitals, HIV infection (OR: 4.1, 95% CI: 2.3-7.1) and age <1 year (OR: 3.7, 95% CI: 1.9-7.2) were independently associated with death, whereas duration of hospitalization ≥5 days (OR: 0.5, 95% CI: 0.3-0.8) and any respiratory virus detection (OR: 0.4, 95% CI: 0.3-0.8) were negatively associated with death. Conclusion: We found that the case-fatality proportion was substantially higher among children admitted to rural hospitals and HIV infected children with SARI in South Africa. While efforts to prevent and treat HIV infections in children may reduce SARI deaths, further efforts to address health care inequality in rural populations are needed.Item TLR genetic variation is associated with Rotavirus-specific IgA seroconversion in South African Black infants after two doses of Rotarix vaccineThabiso Miya; Michelle Groome; Debra De Assis RosaItem Trends in COVID19 admissions and deaths among people living with HIV in South Africa analysis of national surveillance dataWaasila Jassat; Caroline Mudara; L Ozougwu; R Welch; Michelle Groome; Ian Sanne; Cheryl Cohen; Et alItem Vaccine value profile for norovirusG Armah; B A Lopman; J Vinjé; M O'Ryan; Michelle Groome; E et al