Browsing by Author "Lisa Micklesfield"
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Item Adiposity phenotypes and subclinical atherosclerosis in adults from subSaharan Africa a H3AfricaAWIGen studyE Nonterah; M Bots; A Oduro; G Agongo; Cassandra Soo; Lisa Micklesfield; Alisha Wade; Shane Norris; Stephen Tollman; Michele Ramsay; Kerstin Klipstein-Grobusch; Nigel CrowtherItem The association of menopause with cardiometabolic disease risk factors in women living with and without HIV in subSaharan Africa Results from the AWIGen 1 study(ELSEVIER IRELAND LTD) Raylton Chikwati; Nicole Jaff; Nasrin Goolam Mahyoodeen; Lisa Micklesfield; Michele Ramsay; Francesc Gomez-Olive Casas; S F Mohamed; S S R Choma; Jaya George; Nigel CrowtherItem Changes in peripheral quantitative computed tomography measured bone density size and strength in Zimbabwean children with and without HIV over one year a cohort study(WILEY-BLACKWELL) C Mukwasi-Kahari; C Gregson; M Ó Breasail; R Rukuni; Lisa Micklesfield; E et alItem Disparities in fragility fracture and osteoporosis care in AfricaKate A Ward; Tafadzwa Madanhire; Kebba Marenah; Lisa Micklesfield; Celia L GregsonItem Estimating the burden of cardiovascular risk in community dwellers over 40 years old in South Africa Kenya Burkina Faso and GhanaRyan Wagner; Nigel Crowther; Lisa Micklesfield; R Boua; E Nonterah; F Mashinya; S Mohamed; E et al; Stephen Tollman; Michele Ramsay; Justine DaviesItem Genetic Association and Transferability for Urinary AlbuminCreatinine Ratio as a Marker of Kidney Disease in four SubSaharan African Populations and noncontinental Individuals of African AncestryJean-Tristan Brandenburg; Wenlong Chen; Palwende Boua; Melanie A Govender; G Agongo; Lisa Micklesfield; H Sorgho; Stephen Tollman; G Asiki; Scott Hazelhurst; June Fabian; Michele Ramsay; E et alItem Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans(2022-02-14) Palwende Romuald Boua; Jean-Tristan Brandenburg; Ananyo Choudhury; Hermann Sorgho; Engelbert A Nonterah; Godfred Agongo; Gershim Asiki; Lisa Micklesfield; Solomon Choma; Francesc Xavier Gómez-Olivé; Scott Hazelhurst; Halidou Tinto; Nigel J Crowther; Christopher G Mathew; Michèle RamsayAtherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead SNPs in linkage disequilibrium with SNPs primarily identified in European populations. Our study find significant enrichment for genes involved in oestrogen response from female-specific signals. The genes identified show biological relevance to atherosclerosis and/or CVDs, sex-differences and transferability of signals from non-African studies.Item Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study(2018-07-12) Stuart A. Al; Cassandra Soo; Godfred Agongo; Marianne Alberts; Lucas Amenga-Etego; Romuald P. Boua; Ananyo Choudhury; Nigel J. Crowther; Cornelius Depuur; F. Xavier GómezOlivé; Issa Guiraud; Tilahun N. Haregu; Scott Hazelhurst; Kathleen Kahn; Christopher Khayeka-Wandabwa; Catherine Kyobutung; Zané Lombard; Felistas Mashinya; Lisa Micklesfield; Shukri F. Mohamed; Freedom Mukomana; Seydou Nakanabo-Diallo; Hamtandi M. Natama; Nicholas Ngomi; Engelbert A. Nonterah; Shane A. Norris; Abraham R. Oduro; Athanase M. Somé; Hermann Sorgho; Paulina Tindana; Halidou Tinto; Stephen Tollman; Rhian Twine; Alisha Wade; Osman Sankoh; Michèle RamsayThere is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Africa (SSA). We developed a population-based cross-sectional study of disease burden and phenotype in Africans, across six centres in SSA. These centres are in West Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale and Soweto). A total of 10,702 individuals between the ages of 40 and 60 years were recruited into the study across the six centres, plus an additional 1021 participants over the age of 60 years from the Agincourt centre. We collected socio-demographic, anthropometric, medical history, diet, physical activity, fat distribution and alcohol/tobacco consumption data from participants. Blood samples were collected for disease-related biomarker assays, and genomic DNA extraction for genome-wide association studies. Urine samples were collected to assess kidney function. The study provides base-line data for the development of a series of cohorts with a second wave of data collection in Phase 2 of the study. These data will provide valuable insights into the genetic and environmental influences on CMD on the African continentItem The impact of HIV infection on skeletal maturity in peripubertal children in Zimbabwe a crosssectional study(BIOMED CENTRAL LTD) F Kowo-Nyakoko; C Gregson; Leo D Westbury; Tafadzwa Madanhire; Lisa Micklesfield; et al et alItem Influence of vitamin D supplementation on bone mineral content bone turnover markers and fracture risk in South African school children Multicenter doubleblind randomized placebocontrolled trial ViDiKids(WILEY-BLACKWELL) Keren Middelkoop; Lisa Micklesfield; Neil Walker; Justine Stewart; Carmen Delport; Amy Mendham; et al et alItem Influence of vitamin D supplementation on growth body composition pubertal development and spirometry in South African schoolchildren a randomised controlled trial ViDiKidsKeren Middelkoop; Lisa Micklesfield; Justine Stewart; Neil Walker Walker; David A Jolliffe; Amy Mendham; et al et alItem Multisectoral interventions for urban health in Africa a mixedmethods systematic review(CO-ACTION PUBLISHING) M Thondoo; E Mogo; L Tatah; Monica Muti; K Daalen; T Muzenda; Gudani Mukoma; Sostina Matina; Lisa Micklesfield; E "et al"Item Postprandial glucose variability and clusters of sex hormones liver enzymes and cardiometabolic factors in a South African cohort of African ancestryBontle Masango; Julia Goedecke; Michele Ramsay; Karl-Heinz Storbeck; Lisa Micklesfield; Tinashe ChikoworeItem Relationship between Body Mass Index and Body Image Disturbances among South African Mothers and Their Daughters Living in Soweto JohannesburgEmmanuel Cohen; Philippe Gradidge; Lisa Micklesfield; Shane NorrisItem Sarcopenic Obesity in Africa A Call for Diagnostic Methods and Appropriate InterventionsAmy Mendham; L Lundin-Olsson; JH Goedecke; Lisa Micklesfield; DL Christensen; IJ Gallagher; - et alItem SHBG Free Testosterone and Type 2 Diabetes Risk in Middleaged African Men A Longitudinal StudyIkanyeng D Seipone; Amy Mendham; Karl-Heinz Storbeck; Imken Oestlund; Clement Kufe Nyuyki; Tinashe Chikowore; Maphoko Masemola; Nigel Crowther; Andre Pascal Kengne; Shane Norris; Lisa Micklesfield; Julia Goedecke; et al et alItem Silhouette showcards confirm altered obesityassociated body image perception in international cohort study of Africanorigin populations(BMJ PUBLISHING GROUP) C Choo-Kang; T Reese; Lisa Micklesfield; Pascal Bovet; Kweku Bedu-Addo; et al et alItem Variability of polygenic prediction for body mass index in Africa(BIOMED CENTRAL LTD) Tinashe Chikowore; Kristi Lall; Lisa Micklesfield; Zane Lombard; Julia Goedecke; Segun Fatumo; Shane Norris; Reedik Magi; Michele Ramsay; Paul W Franks; E et alItem Virtual Assessment of Physical ActivityRelated Built Environment in Soweto South Africa What Is the Role of Contextual FamiliarityMotlatso Godongwana; Khulu Gama; Vongani Maluleke; Lisa Micklesfield; D Odekunle; Y Wasnyo; B Elouna; E Ngwa; E et al