Browsing by Author "Larske Soepnel"
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Item Are cardiovascular health measures heritable across three generations of families in Soweto, South Africa? A cross-sectional analysis using the random family method(2022-09-23) Lisa J Ware; Innocent Maposa; Andrea Kolkenbeck-Ruh; Shane A Norris; Larske Soepnel; Simone Crouch; Juliana Kagura; Sanushka Naidoo; Wayne Smith; Justine DaviesObjectives: Cardiovascular disease is increasing in many low and middle-income countries, including those in Africa. To inform strategies for the prevention of cardiovascular disease in South Africa, we sought to determine the broad heritability of phenotypic markers of cardiovascular risk across three generations. Design: A cross-sectional study conducted in a longitudinal family cohort. Setting: Research unit within a tertiary hospital in a historically disadvantaged, large urban township of South Africa. Participants: 195 individuals from 65 biological families with all three generations including third-generation children aged 4-10 years were recruited from the longest running intergenerational cohort study in Africa, the Birth to Twenty Plus cohort. All adults (grandparents and parents) were female while children were male or female. Primary and secondary outcome measures: The primary outcome was heritability of blood pressure (BP; brachial and central pressures). Secondary outcomes were heritability of arterial stiffness (pulse wave velocity), carotid intima media thickness (cIMT) and left ventricular mass indexed to body surface area (LVMI). Results: While no significant intergenerational relationships of BP or arterial stiffness were found, there were significant relationships in LVMI across all three generations (p<0.04), and in cIMT between grandparents and parents (p=0.0166). Heritability, the proportion of phenotypic trait variation attributable to genetics, was estimated from three common statistical methods and ranged from 23% to 44% for cIMT and from 21% to 39% for LVMI. Conclusions: Structural indicators of vascular health, which are strong markers of future clinical cardiovascular outcomes, transmit between generations within African families. Identification of these markers in parents may be useful to trigger assessments of preventable risk factors for cardiovascular disease in offspring.Item Integration of nutrition support using the FIGO nutrition checklist in the Bukhali trial: a dietitian's perspectiveMphothokgo Mogashoa; Shane Norris; Khuthala Mabetha; Larske Soepnel; Catherine DraperItem Maternal and neonatal outcomes following the introduction of oral hypoglycaemic agents for gestational diabetes mellitus were comparable to insulin monotherapy in two historical cohortsVeronique Nicolaou; Larske Soepnel; Kenneth Huddle; N Levitt; Kerstin Klipstein-Grobusch; Shane NorrisItem Mobile Technology Use in Clinical Research Examining Challenges and Implications for Health Promotion in South Africa Mixed Methods StudyKhuthala Mabetha; Larske Soepnel; Gugulethu Mabena; Molebogeng Motlhatlhedi; Howard Nyati; Shane Norris; Catherine DraperItem A qualitative analysis of community health worker perspectives on the implementation of the preconception and pregnancy phases of the Bukhali randomised controlled trialLarske Soepnel; Shane Norris; Khuthala Mabetha; Molebogeng Motlhatlhedi; Nokuthula Nkosi; S Lye; Catherine DraperItem A qualitative exploration of the reasons and influencing factors for pregnancy termination among young women in Soweto South Africa a Socioecological perspective(BIOMED CENTRAL LTD) Khuthala Mabetha; Larske Soepnel; D SSewanyana; Catherine Draper; S Lye; Shane NorrisItem The role of a community health workerdelivered preconception and pregnancy intervention in achieving a more positive pregnancy experience the Bukhali trial in Soweto South Africa(BIOMED CENTRAL LTD) Larske Soepnel; Khuthala Mabetha; Shane Norris; Molebogeng Motlhatlhedi; Nokuthula Nkosi; Sonja Klingberg; Stephen Lye; Catherine DraperItem You go an extra mile a qualitative study of community health worker perspectives in a health promotion intervention in urban South Africa(BIOMED CENTRAL LTD) Catherine Draper; Larske Soepnel; Khuthala Mabetha; Molebogeng Motlhatlhedi; Nokuthula Nkosi; S. J Lye; Shane Norris