Browsing by Author "Cheryl Cohen"
Now showing 1 - 20 of 37
Results Per Page
Sort Options
Item A Research and Development RD roadmap for influenza vaccines Looking toward the futureKristine A. Moore; Julia T. Ostrowsky; Alison M. Kraigsley; Angela J. Mehr; E et al; Cheryl CohenItem A retrospective observational cohort study of the effect of antenatal influenza vaccination on birth outcomes in Cape Town South Africa 20152016Meredith McMorrow; Liza Rossi; Susan Meiring; Katherine Bishop; Sibongile Walaza; Orienka Hellferscee; Florette Treurnicht; Cheryl Cohen; E et alItem Association of HIV Exposure and HIV Infection With Inhospital Mortality Among Hospitalized Infants 1 Year of Age South Africa 20162018Nicole Wolter; Sibongile Walaza; C von Mollendorf; Anne Von Gottberg; S Tempia; M McMorrow; Jocelyn Moyes; Florette Treurnicht; Orienka Hellferscee; Malefu Moleleki; Mvuyo Makhasi; N Baute; Cheryl CohenItem Comparing adults with severe SARSCoV2 or influenza infection South Africa 20162021F Els; Jacoba Kleynhans; Nicole Wolter; Mignonette Du Plessis; Fahima Moosa; Stefano Tempia; M Makhasi; Jeremy Nel; H Dawood; S Meiring; Anne Von Gottberg; Cheryl Cohen; Sibongile WalazaItem Congenital Rubella Syndrome Surveillance in South Africa using a sentinel site approach A crosssectional studyNkengafac Villyen Motaze; Jack Manamela; Sheilagh Smit; Helena Rabie; Gary Reubenson; Daynia Ballot; David Moore; E et al; Cheryl Cohen; Melinda SuchardItem Coronavirus Host Genomics Study: South Africa (COVIGen-SA)(2022-10-06) Andrew K. May; Heather Seymour; Harriet Etheredge; Heather Maher; Marta C. Nunes; ShabirA.Madhi; SimisoM. Sokhela; W. D. FrancoisVenter; Neil Martinson; Firdaus Nabeemeeah; Cheryl Cohen; Jocelyn Moyes; Sibongile Walaza; Stefano Tempia; Jackie Kleynhans; Anne von Gottberg; Jeremy Nel; Halima Dawood; Ebrahim Variava; Stephen Tollman; Kathleen Kahn; KobusHerbst; EmilyB.Wong; CarolineT.Tiemessen; Alex van Blydenstein; Lyle Murray; Michelle Venter; June Fabian; Miche´le RamsayHowever, continental Africans are yet to be adequately represented in such studies despite the importance of genetic factors in understanding Africa’s response to the pandemic. We describe the development of a research resource for coronavirus host genomics studies in South Africa known as COVIGen-SA—a multicollaborator strategic partnership designed to provide harmonised demographic, clinical, and genetic information specific to Black South Africans with COVID-19. Over 2,000 participants have been recruited to date. Preliminary results on 1,354 SARS-CoV-2 positive participants from four participating studies showed that 64.7% were female, 333 had severe disease, and 329 were people living with HIV. *rough this resource, we aim to provide insights into host genetic factors relevant to African-ancestry populations, using both genome-wide association testing and targeted sequencing of important genomic loci. *is project will promote and enhance partnerships, build skills, and develop resources needed to address the COVID-19 burden and associated risk factors in South African communities.Item COVID-19 vaccine hesitancy in rural South Africa: Deepening understanding to increase uptake and access(2022-05-22) Kathleen Kahn; Audrey Pettifor; Palesa Mataboge; Nicole K Kelly; Duduzile P Mashinini; Harish Nair; Harry Campbell; Cheryl Cohen; F Xavier Gómez-Olivé; Stephen TollmanBackground: To date, COVID-19 vaccine coverage in the African region falls far too short of global goals. Increasing vaccination rates requires understanding barriers to vaccination so that effective interventions that sensitively and effectively address barriers to vaccination can be implemented. Methods: To assess COVID-19 vaccination levels and identify major barriers to vaccine uptake we conducted a population-based, cross-sectional survey among 1662 adults 18 and older from August 25 to October 29 2021 in the Agincourt Health and Socio-Demographic Surveillance System (AHDSS) area, Mpumalanga, South Africa. Results: Half of participants reported receiving a COVID-19 vaccine (50.4%) with 41.1% being fully vaccinated and 9.3% being partially vaccinated; 49.6% were unvaccinated. More women than men were vaccinated (55.5% vs 42.8%, P < 0.001), and older age groups were more likely to be vaccinated than younger age groups (P < 0.001). Among the unvaccinated, 69.0% planned to get vaccinated as soon as possible, while 14.7% reported definitely not wanting the vaccine. Major barriers to vaccination included lacking information on eligibility (12.3%) or where to get vaccinated (13.0%), concerns about side effects (12.5%), and inconvenient hours and locations for vaccination (11.0%). Confidence in the safety and efficacy of COVID-19 vaccines was higher among those vaccinated than unvaccinated (75.3% vs 51.2%, 75.8% vs 51.0%, both P < 0.001, respectively). Conclusions: Increasing vaccination in South Africa beyond current levels will require a concerted effort to address concerns around vaccine safety and increase confidence in vaccine efficacy. Clarifying eligibility and ensuring access to vaccines at times and places that are convenient to younger populations, men, and other vulnerable groups is necessary.Item Detection of Victoria lineage influenza B viruses with K162 and N163 deletions in the hemagglutinin gene South Africa 2018Orienka Hellferscee; Florette Treurnicht; Lucinda Gaelejwe; aLEXANDRA mOERDYK; Gary Reubenson; Meredith McMorrow; Stefano Tempia; Johanna McAnerney; Sibongile Walaza; Nicole Wolter; Anne Von Gottberg; Cheryl CohenItem Diagnosis of communityacquired pneumonia in children South African Thoracic Society guidelines part 2H Zar; David Moore; G Itzikowits; R Green; A Argent; Cheryl Cohen; Gary Reubenson; Shabir Madhi; E et alItem Difference in mortality among individuals admitted to hospital with COVID19 during the first and second waves in South Africa a cohort studyWaasila jassat; Caroline Mudara; Lovelyn Ozougwu; Stefano Tempia; Lucille Blumberg; E et al; Anne Von Gottberg; Jinal Bhiman; Cheryl Cohen; Sibongile WalazaItem Differential inhospital mortality and intensive care treatment over time Informing hospital pathways for modelling COVID19 in South AfricaLise Jamieson; Cari Van Schalkwyk; Brooke E Nicholas; Gesine Meyer-Rath; Sheetal Silal; Juliet Pulliam; L Blumberg; Cheryl Cohen; Harry Moultrie; Waasila JassatItem Epidemiology of Pertussis in Individuals of All Ages Hospitalized With Respiratory Illness in South Africa January 2013December 2018Nicole Wolter; Cheryl Cohen; Stefano Tempia; Sibongile Walaza; Fahima Moosa; Mignonette Du Plessis; Meredith L McMorrow; Florette Treurnicht; Orienka Hellferscee; Halima Dawood; Ebrahim Variava; Anne Von GottbergItem Estimated impact of the pneumococcal conjugate vaccine on pneumonia mortality in South Africa 1999 through 2016 An ecological modelling studyJ Kleynhans; Stefano Tempia; Kayoko Shioda; Anne Von Gottberg; Daniel Weinberger; Cheryl CohenItem Estimating household contact matrices structure from easily collectable metadata(PUBLIC LIBRARY SCIENCE) L Amico; Jacoba Kleynhans; L Gauvin; M Tizzoni; L Ozella; Nicole Wolter; Cheryl Cohen; Stefano Tempia; E "et al"Item Estimating the contribution of HIV-infected adults to household pneumococcal transmission in South Africa, 2016–2018: A hidden Markov modelling study(2021-12-23) Deus Thindwa; Nicole Wolter; Amy Pinsent; Maimuna CarrimI; John Ojal; Stefano Tempia; Jocelyn Moyes; Meredith McMorrow; Jackie Kleynhans; Anne von Gottberg; Neil French; PHIRST group; Cheryl Cohen; Stefan FlascheHuman immunodeficiency virus (HIV) infected adults are at a higher risk of pneumococcal colonisation and disease, even while receiving antiretroviral therapy (ART). To help evaluate potential indirect effects of vaccination of HIV-infected adults, we assessed whether HIV-infected adults disproportionately contribute to household transmission of pneumococci. We constructed a hidden Markov model to capture the dynamics of pneumococcal carriage acquisition and clearance observed during a longitudinal household-based nasopharyngeal swabbing study, while accounting for sample misclassifications. Households were followed-up twice weekly for approximately 10 months each year during a three-year study period for nasopharyngeal carriage detection via real-time PCR. We estimated the effect of participant’s age, HIV status, presence of a HIV-infected adult within the household and other covariates on pneumococcal acquisition and clearance probabilities. Of 1,684 individuals enrolled, 279 (16.6%) were younger children (<5 years-old) of whom 4 (1.5%) were HIV-infected and 726 (43.1%) were adults (�18 years-old) of whom 214 (30.4%) were HIV-infected, most (173, 81.2%) with high CD4+ count. The observed range of pneumococcal carriage prevalence across visits was substantially higher in younger children (56.9– 80.5%) than older children (5–17 years-old) (31.7–50.0%) or adults (11.5–23.5%). We estimate that 14.4% (95% Confidence Interval [CI]: 13.7–15.0) of pneumococcal-negative swabs were false negatives. Daily carriage acquisition probabilities among HIV-uninfected younger children were similar in households with and without HIV-infected adults (hazard ratio: 0.95, 95%CI: 0.91–1.01). Longer average carriage duration (11.4 days, 95%CI: 10.2– 12.8 vs 6.0 days, 95%CI: 5.6–6.3) and higher median carriage density (622 genome equivalents per millilitre, 95%CI: 507–714 vs 389, 95%CI: 311.1–435.5) were estimated in HIVinfected vs HIV-uninfected adults. The use of ART and antibiotics substantially reduced carriage duration in all age groups, and acquisition rates increased with household size. Although South African HIV-infected adults on ART have longer carriage duration and density than their HIV-uninfected counterparts, they show similar patterns of pneumococcal acquisition and onward transmission.Item Estimating the costeffectiveness of maternal vaccination and monoclonal antibodies for respiratory syncytial virus in Kenya and South Africa(BIOMED CENTRAL LTD) Koltai Mihaly; Jocelyn Moyes; Bryan Nyawanda; Joyce Nyiro; Patrick Munywoki; Stefano Tempia; Cheryl Cohen; E et alItem Estimating the timevarying reproduction number for COVID19 in South Africa during the first four waves using multiple measures of incidence for public and private sectors across four waves(PUBLIC LIBRARY SCIENCE) J Bingham; Stefano Tempia; Henry Moultrie; C Viboud; W Jassat; Cheryl Cohen; J PulliamItem Genomic characterization of Bordetella pertussis in South Africa 20152019Fahima Moosa; Mignonette Du Plessis; M.R Weigand; Y Peng; D Mogale; L de Gouveia; Martha Nunes; Shabir Madhi; E et al; Gary Reubenson; Cheryl Cohen; Sibongile Walaza; Anne Von Gottberg; Nicole WolterItem Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018 a systematic review and modelling studyXin Wang; You Li; Katherine L O'Brien; Shabir Madhi; Marc-Alain Widdowson; Peter Byass; Cheryl Cohen; Michelle Groome; Florette Treurnicht; E et alItem Healthcare seeking behaviour for common infectious syndromes among people in three administrative regions of Johannesburg South Africa 2015 a crosssectional studyRelebogile Mapuroma; Cheryl Cohen; Lazarus Kuonza; Alfred Musekiwa; Stefano Tempia; Akhona Tshangela; Claire Von Mollendorf