Browsing by Author "Chanel Robinson"
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Item Cardiovascular Risk Factor Profiles and Disease in Black Compared to Other Africans with Chronic Kidney Disease(2020-12-14) Hon-Chun Hsu; Chanel Robinson; Angela J. Woodiwiss; Gavin R. Norton; Patrick H. DesseinBackground and Objectives. *e extent to which chronic kidney disease (CKD) impacts cardiovascular disease (CVD) in black Africans is uncertain. We compared cardiovascular risk factors and CVD between black and other African CKD patients. Methods. Cardiovascular risk factors, aortic and cardiac function, atherosclerosis extent, and cardiovascular event rates were assessed in 115 consecutive predialysis (n = 67) and dialysis patients (n = 48) including 46 black and 69 other (32 Asian, 28 white, and 9 mixed race) participants. Data were analysed in multivariable regression models. Results. Overall, black compared to other African CKD patients had less frequent carotid artery plaque (OR (95% CI) = 0.38 (0.16–0.91)) despite an increased cardiovascular risk factor burden. In receiver operator characteristic curve analysis, the Framingham score performed well in identifying nonblack but not black CKD patients with carotid plaque (area under the curve (AUC) (95% CI) = 0.818 (0.714–0.921) and AUC (95% CI) = 0.556 (0.375–0.921), respectively). Black compared to other African predialysis patients experienced larger Framingham scores and more adverse nontraditional cardiovascular risk factors, impaired arterial and diastolic function but similar cardiovascular event rates (OR (95% CI) = 0.93 (0.22 to 3.87)). Among dialysis patients, black compared to other Africans had an overall similar traditional and nontraditional cardiovascular risk factor burden, similar arterial and diastolic function but increased systolic function (partial R = 0.356, p = 0.01 and partial R = 0.315, p = 0.03 for ejection fraction and stroke volume, respectively) and reduced cardiovascular event rates (OR (95% CI) = 0.22 (0.05 to 0.88)). Conclusion. Black compared to other African CKD patients have less frequent very high risk atherosclerosis and experience weaker cardiovascular risk factor-atherosclerotic CVD relationships. *ese disparities may be due to differences in epidemiological health transition stages. Among dialysis patients, black compared to other Africans have less cardiovascular events, which may represent a selection bias as previously documented in black Americans.Item Carotid intima-media thickness, but not chronic kidney disease independently associates with noncardiac arterial vascular events in South AfricaAndrea Kolkenbeck-Ruh; Angela Woodiwiss; Ravi Naran; Mohammad Sadiq; Chanel Robinson; Harold Motau; Teboho Monareng; Philanathi Mabena; Nomvuyo Manyatsi; Zonga Gazwa; Abu Abdool-Carrim; Olebogeng Majane; Martin Veller; Girish Modi; Gavin NortonItem Diabetic nephropathyassociated impaired aortic function is not mediated by mean arterial pressure and its determinantsHon-Chun Hsu; Makabongwe Mazibuko; Chanel Robinson; N Dlongolo; Angela Woodiwiss; Gloria Teckie; Oluwatosin Tade; Patrick DesseinItem Early wave reflection and pulse wave velocity are associated with diastolic dysfunction in rheumatoid arthritisLebogang Mokotedi; Sule Gunter; Chanel Robinson; Frederic Michel; Ahmed Solomon; Gavin Norton; Angela Woodiwiss; Linda Tsang; Patrick Dessein; Aletta MillenItem Independent of left ventricular mass circulating inflammatory markers rather than pressure load are associated with concentric left ventricular remodellingGavin Norton; Vernice Peterson; Chanel Robinson; Glenda Norman; Carlos Libhaber; Elena Libhaber; Monica Gomes; Pinchas Sareli; Angela WoodiwissItem The relative potential contribution of volume load and vascular mechanisms to hypertension in nondialysis and dialysis chronic kidney disease patientsOluwatosin Tade; Hon-Chun Hsu; Chanel Robinson; N Dlongolo; Gloria Teckie; Ahmed Solomon; Patrick DesseinItem The optimal haemoglobin target in dialysis patients may be determined by its contrasting effects on arterial stiffness and pressure pulsatilityHon-Chun Hsu; Chanel Robinson; Gavin Norton; Angela Woodiwiss; Patrick Dessein