Molecular characterization of multidrug-resistant Salmonella Isangi in hospitalized patients
| dc.contributor.author | Kruger, Tersia | |
| dc.date.accessioned | 2008-08-19T09:22:39Z | |
| dc.date.available | 2008-08-19T09:22:39Z | |
| dc.date.issued | 2008-08-19T09:22:39Z | |
| dc.description.abstract | ABSTRACT Extended-spectrum beta-lactamase (ESBL)-producing Salmonella enterica serotype Isangi has emerged as a common Salmonella serotype affecting mainly children in hospitals throughout South Africa. Between 2000 and 2002, 279 S. Isangi isolates from single infection episodes were referred from 21 hospitals in 5 provinces to the Enteric Diseases Reference Unit of the National Institute for Communicable Diseases of South Africa. All isolates were subjected to antibiotic susceptibility testing and three disk-diffusion methods confirmed ESBL-production in 273 isolates. PCR and nucleotide sequencing of 101 isolates identified TEM-1 (2%), TEM-63 (91%), a novel TEM-131 (7%), and SHV-5 (2%), but CTX-M was not found. Plasmid profiling produced types with 1 to 6 plasmids, 7.4kb to 166kb in size, which were neither serotype nor ESBL-type specific. Pulsed-field gel electrophoresis revealed four major clusters while sub-clusters with identical, or near identical banding patterns suggested extensive intra-hospital transmission and clonal spread between hospitals and provinces in South Africa. | en |
| dc.format.extent | 223721 bytes | |
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| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/10539/5429 | |
| dc.language.iso | en | en |
| dc.subject | molecular epidemiology | en |
| dc.subject | multidrug-resistant | en |
| dc.subject | Salmonella Isangi | en |
| dc.subject | South Africa | en |
| dc.title | Molecular characterization of multidrug-resistant Salmonella Isangi in hospitalized patients | en |
| dc.type | Thesis | en |
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