á-Catenin expression in oesophageal squamous cell carcinoma

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dc.contributor.author Schnugh, Desmond Jo
dc.date.accessioned 2006-03-23T12:34:09Z
dc.date.available 2006-03-23T12:34:09Z
dc.date.issued 2006-03-23
dc.identifier.uri http://hdl.handle.net/10539/284
dc.description Master of Science - Biology en
dc.description.abstract á-catenin plays a crucial role in cell adhesion. Expression levels of á-catenin have been shown to be decreased in almost all tumours studied. The levels of the epidermal growth factor receptor (EGFR) were shown to be increased in oesophageal squamous cell carcinoma (OSCC) cell lines. á-catenin therefore, may play a part in linking the EGF pathway or other signal transduction pathways, bringing about some of the changes in the OSCC cell lines. The á-catenin gene from five OSCC cell lines was sequenced. Three out of five OSCC cell lines studied were found to harbour mutations. One of the mutations resulted in a change in the amino acid sequence of á-catenin. It was concluded that this alteration may not have affected the functioning of á-catenin. á-catenin was largely expressed at the plasma membrane with some weaker cytoplasm/nuclear expression occurring in all of the OSCC cell lines. Treatment of the OSCC cells with EGF for a 12 hour period resulted in no noticeable change in the expression levels of á- catenin. The results obtained from this study indicated that á-catenin could play a role in signal transduction pathways in the OSCC cell lines. en
dc.format.extent 42771 bytes
dc.format.extent 1463523 bytes
dc.format.extent 28103 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso en
dc.subject carcinoma en
dc.subject cell en
dc.subject squamous en
dc.subject oesophageal en
dc.subject catenin en
dc.title á-Catenin expression in oesophageal squamous cell carcinoma en
dc.type Thesis en


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    Thesis (Ph.D.)--University of the Witwatersrand, 1972.

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