Functional studies of the RBBP6 (retinoblastoma binding protein 6) gene and its related genes in breast and cervical cancer : a promising diagnostic and management assay for cancer progression
Date
2016
Authors
Moela, Pontsho
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Abstract
Overexpression of RBBP6 in cancers of the colon, lung and oesophagus makes it a potential
target in anticancer therapy. This is especially important because it associates with the tumour
suppressor gene p53, inactivation of which has been linked to over 50% of all cancer types.
Cancer is an enormous burden of a disease globally. Today, more people die from cancer than
HIV/AIDS, tuberculosis and malaria combined. And in females, breast and cervical malignancies
remain the most common types. Currently, cervical cancer is the most diagnosed gynaecological
cancer type, whose mortality rate is the highest in developing countries due to the asymptomatic
nature of the disease coupled with inadequate cancer control tools and facilities. Breast cancer
incidence rate has increased beyond that of lung cancer, making it the most common malignancy
among women.
Description
A thesis submitted to the Faculty of Science under the school of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Doctor of Philosophy. Gauteng, Johannesburg, 2016.