Functional studies of the RBBP6 (retinoblastoma binding protein 6) gene and its related genes in breast and cervical cancer : a promising diagnostic and management assay for cancer progression

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dc.contributor.authorMoela, Pontsho
dc.date.accessioned2016-10-19T10:06:33Z
dc.date.available2016-10-19T10:06:33Z
dc.date.issued2016
dc.descriptionA thesis submitted to the Faculty of Science under the school of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Doctor of Philosophy. Gauteng, Johannesburg, 2016.
dc.description.abstractOverexpression of RBBP6 in cancers of the colon, lung and oesophagus makes it a potential target in anticancer therapy. This is especially important because it associates with the tumour suppressor gene p53, inactivation of which has been linked to over 50% of all cancer types. Cancer is an enormous burden of a disease globally. Today, more people die from cancer than HIV/AIDS, tuberculosis and malaria combined. And in females, breast and cervical malignancies remain the most common types. Currently, cervical cancer is the most diagnosed gynaecological cancer type, whose mortality rate is the highest in developing countries due to the asymptomatic nature of the disease coupled with inadequate cancer control tools and facilities. Breast cancer incidence rate has increased beyond that of lung cancer, making it the most common malignancy among women.en_ZA
dc.description.librarianGR2016en_ZA
dc.identifier.urihttp://hdl.handle.net/10539/21249
dc.language.isoenen_ZA
dc.subject.lcshBreast--Cancer
dc.subject.lcshProtein binding
dc.subject.lcshCervix uteri--Cancer
dc.titleFunctional studies of the RBBP6 (retinoblastoma binding protein 6) gene and its related genes in breast and cervical cancer : a promising diagnostic and management assay for cancer progressionen_ZA
dc.typeThesisen_ZA
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