Genotoxicity of mycotoxins in an improved drosophila wing spot test and other short-term effects
Date
1992
Authors
Pacella, Rosana Elizabeth
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Attempts have been made recently to improve the Drosophiia Somatic
Mutation and Recombination wing spot test (SMART) by inciudjig insecticide
resistance genes that confer high bioactivation (HB) to SMART tester strains.
A drawback of the HB lines is the presence of whorling of wing hairs which
interferes with scoring for mutant spots. The gene responsible for this whorling
effect, which I have named paisley (ply), was shown to be recessive and
located around position 90 on chromosome 2 and is thus linked to the RI gene
responsible for the high constitutive expression of cytochrome P450-
dependent activities typical of HB strains. (Abbreviation abstract)
Description
A Thesis Submitted to the Faculty of Science, University of the Witwatersrand,
Johannesburg in Fulfilment of the Requirements for the Degree of Doctor
of Philosophy.
Keywords
Genetics -- Data processing., Drosophila., Genetic toxicology., Micotoxins., Mutation (Biology), Mutation (Biology), SMART (Information retrieval system)