A role for transforming growth factor alpha and its receptor in human oesophageal cancer
Date
1993
Authors
Jones, Gregory Justin
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A member of the epidermal growth factor (EGF) family; transforming
growth factor alpha (TGF-a) shares significant homology with EGF and
binds to the EGF receptor (EGF-R). Like EGF TGF-a plays important
roles in normal physiological processes; but, as its name signifies, it has
potent transforming ability; often associated with autocrine stimulatory
mechanisms. The purpose of this study is to investigate a possible role
for TGF-a and its receptor in certam human oesophageal squamous cell
carcinoma (SCC) cell lines - namely, WHCO-I, -3 and -5. The wellstudied
A431 epidermoid. carcinoma cell line was used throughout for
control purposes. (Abbreviation abstract)
Description
A dissertation submitted to the Faculty of Science, University of the
Witwatersrand, Johannesburg, in fulfilment of the requirements for the
degree of Master of Science.
Keywords
Transforming growth factors., Epidermal growth factor., Esophagus -- Cancer.