Calculations of Radiobiological Treatment Outcome in Rhabdomyosarcoma

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dc.contributor.author Nyathi, Thulani
dc.date.accessioned 2007-03-15T12:50:32Z
dc.date.available 2007-03-15T12:50:32Z
dc.date.issued 2007-03-15T12:50:32Z
dc.identifier.uri http://hdl.handle.net/10539/2271
dc.description Thulani Nyathi, Student no: 0413256X, MSc thesis, Physics, Faculty of science. 2006. Supervisor: Prof D van der Merwe. en
dc.description.abstract This study aims to calculate tumour control probabilities (TCP) and normal tissue complication probabilities (NTCP) using radiobiological models and correlate these probabilities with clinically observed treatment outcome from follow-up records. These radiobiological calculations were applied retrospectively to thirty-nine paediatric patients who were treated with radiation at Johannesburg Hospital during the period January 1990 to December 2000 and had histologically proven rhabdomyosarcoma. Computer software, BIOPLAN, was used to calculate the TCP and NTCP arising from the dose distribution calculated by the treatment planning system and characterized by dosevolume histograms (DVHs). There was a weak correlation between the calculated TCP and the observed 5-year overall survival status. Furthermore, potential prognostic factors for survival were examined. Statistical analysis was performed using the Cox proportional hazards regression model. The 5-year overall survival rate was 55 %. The findings of this study are a yardstick against which more aggressive radiotherapy fractionation regimes can be compared. en
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dc.language.iso en en
dc.subject TCP en
dc.subject NTCP en
dc.subject radiobiological models en
dc.subject correlation en
dc.subject radiation en
dc.subject rhabdomyosarcoma en
dc.subject bioplan en
dc.subject DVH en
dc.subject prognostic factors en
dc.subject overall survival en
dc.title Calculations of Radiobiological Treatment Outcome in Rhabdomyosarcoma en
dc.type Thesis en


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