The role of nucleophosmin fusion sequences in the oncogenic activation of the (2;5) translocation protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)
Date
1996
Authors
Bischof, Daniela
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Abstract
The NPM-ALK fusion gene, formed by the t(2;5)(p23;q35) in non-Hodgkin's
lymphoma encodes a 75kDa hybrid protein that contains the amino-terminal
118 amino acid residues of the nucleolar phosphoprotein nucleophosmin
(NPM) joined to the entire cytoptasmic portion of the receptor tyrosine
kinase, anaplastic lymphoma kinase (ALK). The transforming ability of NPM-ALK
is demonstrated and it is shown that oncogenesis by the chimaeric
protein requires the activation of its kinase function as a result of
oligomerisation mediated by the NPM segment. [Abbreviated Abstract. Open document to view full version]
Description
A thesis submitted to the Faculty of Science, University of the
Witwatersrand, Johannesburg, South Africa, in fulfillment of the requirements
for the degree of Doctor of Philosophy.
Johannesburg, 1996
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Citation
Bischof, Daniela (2016) The role of nucleophosmin fusion sequences in the oncogenic activation of the (2;5) translocation protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), University of Witwatersrand, Johannesburg, <http://wiredspace.wits.ac.za/handle/10539/20829>