New purine analogues as inhibitors of purine metabolism
Date
2015
Authors
Rama, Dhirajlal Bhagwan Kasan
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Abstract
Abstract
Phleomycin, a copper containing protein, has a broad range of antibiotics (3,4,6) anti tumor (7,9), and anti-viral (5) activity. At low concentrations it induces DNA breakdown and death in growing culture is of E. coli B, but has little effect on stationary phase bacteria (10) . However, its action can be strongly potentiated on stationary phase cells by the addition of certain compounds. This phenomenon is termed amplification.The mechanism of amplification phleomycin is not well understood. In this study the effects of various purine and pyrimidine analogues reported as amplifiers of phleomycin (2) were investigated on several aspects of nucleotide metabolism.