Causes and predictors of death in South Africans with systemic lupus erythematosus

Show simple item record Wadee, Shoyab 2006-11-14T11:02:34Z 2006-11-14T11:02:34Z 2006-11-14T11:02:34Z
dc.description Faculty of Health School of Medicine 9101327d en
dc.description.abstract Little is known about the epidemiological and mortality patterns of systemic lupus erythematosus (SLE) in Africa. Aims of this study- to determine the demographics, clinical features and causes and predictors death in patients attending the Lupus clinic at the Chris Hani Baragwanath hospital in Soweto. Methods- the records of 226 patients who fulfilled American College of Rheumatism criteria for the diagnosis of SLE were reviewed. The mean (± SD) age at presentation was 34 (± 12.5) years. The female to male ratio was 18:1. The commonest clinical feature found was arthritis in 70.4% of patients. Nephritis was present in 43.8% and CNS lupus in 15.9% of patients. 55 patients in this group had died and 64 were lost to follow up. The 5-year survival was 57% uncensored and 72% if censored for loss to follow up. Infection (32.7%) was the commonest cause of death followed by renal failure (16.4%). Nephritis, CNS lupus and hypocomplementaemia were associated with mortality on univariate analysis. Lupus nephritis was the only independant predictor of mortality on multivariate analysis. Conclusion- this study confirms the poor outcome of SLE in the developing world and demonstrates that renal disease is a factor commonly implicated in mortality. The 5-year survival and pattern of mortality is similar to that reported elsewhere in the developing world en
dc.format.extent 348143 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.subject Systemic lupus en
dc.subject Mortality en
dc.subject Renal involvement en
dc.subject erythematosis en
dc.title Causes and predictors of death in South Africans with systemic lupus erythematosus en
dc.type Thesis en

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