Automatic Minimisation of Patient Setup Errors in Proton Beam Therapy

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dc.contributor.author Ransome, Trevor Malcolm
dc.date.accessioned 2006-11-14T09:19:26Z
dc.date.available 2006-11-14T09:19:26Z
dc.date.issued 2006-11-14T09:19:26Z
dc.identifier.uri http://hdl.handle.net/10539/1667
dc.description Student Number : 0003555T - MSc (Eng) dissertation - School of Electrical and Information Engineering - Faculty of Engineering and the Built Environment en
dc.description.abstract Successful radiotherapy treatments with high-energy proton beams require the accurate positioning of patients. This paper investigates computational methods for achieving accurate treatment setups in proton therapy based on the geometrical differences between a double exposed portal radiograph (PR) and a reference image obtained from the treatment planning process. The first step in these methods involves aligning the boundary of the radiation field in the PR with a reference boundary defined by the treatment plan. We propose using the generalised Hough transform (GHT), followed by an optimisation routine to align the field boundaries. It is found that this method worked successfully on ten tested examples, and aligns up to 82% of reference boundary points onto the field boundary. The next step requires quantising the patients anatomical shifts relative to the field boundary. Using simulated images, a number of intensity-based similarity measures and optimisation routines are tested on a 3D/2D registration. It is found that the simulated annealing algorithm minimising the correlation coefficient provided the most accurate solution in the least number of function evaluations. en
dc.format.extent 900347 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.subject minimisation en
dc.subject setup errors en
dc.subject radiotherapy en
dc.subject image registration en
dc.title Automatic Minimisation of Patient Setup Errors in Proton Beam Therapy en
dc.type Thesis en


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    Thesis (Ph.D.)--University of the Witwatersrand, 1972.

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