Newby, Eric2013-07-292013-07-292013-07-29http://hdl.handle.net/10539/12914A dissertation submitted to the Faculty of Science School of Computational and Applied Mathematics, University of the Witwatersrand, Johannesburg. April 27, 2013.In a number of situations the derivative of the objective function of an optimization problem is not available. This thesis presents a novel algorithm for solving mixed integer programs when this is the case. The algorithm is the first developed for problems of this type which uses a trust region methodology. Three implementations of the algorithm are developed and deterministic proofs of convergence to local minima are provided for two of the implementations. In the development of the algorithm several other contributions are made. The derivative free algorithm requires the solution of several mixed integer quadratic programming subproblems and novel methods for solving nonconvex instances of these problems are developed in this thesis. Additionally, it is shown that the current definitions of local minima for mixed integer programs are deficient and a rigorous approach to developing possible definitions is proposed. Using this approach we propose a new definition which improves on those currently used in the literature. Other components of this thesis are an overview of derivative based mixed integer non-linear programming, extensive reviews of mixed integer quadratic programming and deterministic derivative free optimization and extensive computational results illustrating the effectiveness of the contributions mentioned in the previous paragraphs.enInteger programming.Nonlinear programming.Programming (Mathematics)General solution methods for mixed integer quadratic programming and derivative free mixed integer non-linear programming problemsThesis