Genetic variation in gp 120 V1?V2 and neutralization sensitivity of HIV-1 subtype C isolates from children with rapid and slow disease progression

Choge, Isaac Ang' Ang' A2018-12-112018-12-112003https://hdl.handle.net/10539/26210a dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg. for the Degree of Master of Science in Medicine (Virology) Johannesburg,. 2003This project explore genetic variation and antibody neutralization sensitivity in gp 120 V1/V2 and C2-V5 region amongst HIV-1 subtype C pediatric isolates. Isolates from 25 slow progressing children and 16 rapid progressing infants were used in subtyping and quasispecies analysis performed with a novel V1/V2 heteroduplex mobility assay (HMA)enHIV Envelope Protein gp120HIV-1ChildDNAGenetic variation in gp 120 V1?V2 and neutralization sensitivity of HIV-1 subtype C isolates from children with rapid and slow disease progressionThesis